中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [24]
采集方式
OAI收割 [24]
内容类型
期刊论文 [24]
发表日期
2024 [1]
2023 [3]
2022 [2]
2021 [1]
2020 [1]
2019 [2]
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专题:上海药物研究所
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7-Dehydrocholesterol dictates ferroptosis sensitivity
期刊论文
OAI收割
NATURE, 2024, 卷号: 626, 期号: 7998, 页码: 29
作者:
Li, Yaxu
;
Ran, Qiao
;
Duan, Qiuhui
;
Jin, Jiali
;
Wang, Yanjin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/04/09
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Prime editing-based gene correction alleviates the hyperexcitable phenotype and seizures of a genetic epilepsy mouse model
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 4
作者:
Cao, Bi-rong
;
Huang, Yi-ming
;
Tian, Fu-yun
;
Li, Jin-hui
;
Xu, Chun-long
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/10/17
The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2023, 页码: 23
作者:
Wang, Xin
;
Lin, Di-Hang
;
Yan, Yue
;
Wang, An-Hui
;
Liao, Jiaoyang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
PIWI
piRNAs
PIWI-Ins
translational activation
spermatid development
male fertility
Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice
期刊论文
OAI收割
BIOMEDICAL CHROMATOGRAPHY, 2022, 页码: 10
作者:
Yuan, Meng
;
Hu, Wenjuan
;
Feng, Yingying
;
Tong, Yue
;
Wang, Xin
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/06/15
diabetic nephropathy
LC-MS
MS
nucleoside
pharmacokinetics
remdesivir
A novel hybrid scan approach enabling the ion-mobility separation and the alternate data-dependent and data-independent acquisitions (HDDIDDA): Its combination with off-line two-dimensional liquid chromatography for comprehensively characterizing the multicomponents from Compound Danshen Dripping Pill
期刊论文
OAI收割
ANALYTICA CHIMICA ACTA, 2022, 卷号: 1193, 页码: 12
作者:
Wang, Hong-da
;
Wang, Hui-min
;
Wang, Xiang-yang
;
Xu, Xiao-yan
;
Hu, Ying
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/08/16
Alternate data-independent and data-dependent acquisition
Ion mobility/quadrupole time-of-flight mass spectrometry
Off-line two-dimensional liquid chromatography
Multicomponent characterization
Compound Danshen dripping pill
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
OAI收割
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
  |  
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats
期刊论文
OAI收割
NEUROSCIENCE BULLETIN, 2020, 卷号: 36, 期号: 4, 页码: 333-345
作者:
Gu, Pan
;
Xu, Zi-Hao
;
Cao, Yu-Ze
;
Liao, Sheng-Hui
;
Deng, Qian-Fang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Epilepsy
Synchrotron radiation
3D
Angioarchitecture
Blood vessel
Remodeling
Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views
期刊论文
OAI收割
JOURNAL OF SYNCHROTRON RADIATION, 2019, 卷号: 26, 页码: 2024-2032
作者:
Li, Hong-Lei
;
Ding, Hui
;
Yin, Xian-Zhen
;
Chen, Zhuo-Hui
;
Tang, Bin
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
2D
3D
brain
microtomography
synchrotron radiation
vascular network
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode