中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 药物化学研究室
Synthesis Study on Marmycin A: Preparation of the C3 '-Desmethyl Analogues

文献类型：期刊论文

作者Ding, Chunyong1,2; Tu, Shanghui2,3; Li, Fuying2; Wang, Yuanxiang2; Yao, Qizheng1; Hu, Wenxiang3; Xie, Hua4; Meng, Linghua4; Zhang, Ao2
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2009-08-21
卷号74期号:16页码:6111-6119
ISSN号0022-3263
DOI10.1021/jo9011078
文献子类Article
英文摘要Total synthesis of natural product marmycin A was studied. An expeditious synthetic strategy for the key fragment 8-amino-3-methylbenz[a]anthraduinone (1) was established with decarboxylative alkylation, Pd(OAc)(2)-catalyzed cyclization, aromatization, and C-N coupling as the key steps. However, final assembly of marmycin A was hampered by the failure to obtain the carbohydrate fragment 2. Instead, a small library of desmethyl analogues of marmycin A was prepared in moderate yields by using the InBr3-catalyzed C- and N-glycosidation reaction. The absolute configuration of these compounds was confirmed by comparison of their spectroscopic data with that reported for marmycin A. and by X-ray analysis.
WOS关键词NATURALLY-OCCURRING QUINONES ; STEREOSELECTIVE-SYNTHESIS ; ANGUCYCLINONE ANTIBIOTICS ; (+)-RUBIGINONE B-2 ; ARYL AMINES ; GLYCALS ; (+)-OCHROMYCINONE ; (-)-TETRANGOMYCIN ; BENZANNULATION ; TETRANGULOL
资助项目State Key Laboratory of Drug Research[SIMM0809KF-02] ; Chinese National Science Foundation[30772625] ; Shanghai Commission of Science and Technology[07pj14104] ; Chinese Academy of Sciences[00000000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000268907300042
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/279155]  
专题药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Yao, Qizheng
作者单位1.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China;
2.SIMM, SOMCL, Shanghai 201203, Peoples R China;
3.Capital Normal Univ, Dept Chem, Beijing, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Chunyong,Tu, Shanghui,Li, Fuying,et al. Synthesis Study on Marmycin A: Preparation of the C3 '-Desmethyl Analogues[J]. JOURNAL OF ORGANIC CHEMISTRY,2009,74(16):6111-6119.
APA Ding, Chunyong.,Tu, Shanghui.,Li, Fuying.,Wang, Yuanxiang.,Yao, Qizheng.,...&Zhang, Ao.(2009).Synthesis Study on Marmycin A: Preparation of the C3 '-Desmethyl Analogues.JOURNAL OF ORGANIC CHEMISTRY,74(16),6111-6119.
MLA Ding, Chunyong,et al."Synthesis Study on Marmycin A: Preparation of the C3 '-Desmethyl Analogues".JOURNAL OF ORGANIC CHEMISTRY 74.16(2009):6111-6119.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。