Synthesis and biological activity of 10-hydroxylated aza-solamin
文献类型：期刊论文
| 作者 | WANG Meng; TANG Weidong; LOU Liguang ; WANG Xin; SHEN Jingkang
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:4页码:214-217 |
| 关键词 | medicinal chemistry compound preparation chemical synthesis aza-solamin acetogenin antitumor |
| ISSN号 | 1005-0108 |
| 其他题名 | 10-羟基氮杂solamin类似物的合成及其生物活性 |
| 文献子类 | Article |
| 英文摘要 | Aim A novel aza-acetogenin analogue was designed and synthesized to study its antitumor activity. Methods Based on the aza-solamin molecular template, 10-hydroxyl aza-solamin was synthesized through multi-step chemical reactions. The antitumor activities of the 10-hydroxyl analogue, along with the precursor compounds, was assessed by inhibiting HL-60, LoVo and HT-29 tumor cells growth in vitro using MTT method. Results The 10-hydroxylated aza-solamin was first synthesized successfully, and its structure was confirmed by IR, 'H-NMR and MS specta. Conclusion The preliminary tests in vitro show that these novel solamin analogues still retain certain antitumor activities, and the polar functional group at alkyl spacer of the moiety would benefit its activity against some tumor cells. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2417643 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268206]  |
| 专题 | 药物化学研究室 药物靶标结构与功能中心 国家新药筛选中心 |
| 作者单位 | State Key Laboratory of Drug Research , Shanghai Institute of Materia Meclica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | WANG Meng,TANG Weidong,LOU Liguang,et al. Synthesis and biological activity of 10-hydroxylated aza-solamin[J]. Chinese Journal of Medicinal Chemistry,2006,16(4):214-217. |
| APA | WANG Meng,TANG Weidong,LOU Liguang,WANG Xin,&SHEN Jingkang.(2006).Synthesis and biological activity of 10-hydroxylated aza-solamin.Chinese Journal of Medicinal Chemistry,16(4),214-217. |
| MLA | WANG Meng,et al."Synthesis and biological activity of 10-hydroxylated aza-solamin".Chinese Journal of Medicinal Chemistry 16.4(2006):214-217. |
入库方式： OAI收割
来源：上海药物研究所
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