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Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)-ones to Quinolin-2(1H)-ones Using Transition-Metal-Activated Persulfate Salts

文献类型：期刊论文

作者Chen, Weiming1,2; Sun, Changliang3; Zhang, Yan4; Hu, Tianwen3; Zhu, Fuqiang3; Jiang, Xiangrui4; Abame, Melkamu Alemu2,4; Yang, Feipu4; Suo, Jin4; Shi, Jing3
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-07-05
卷号84期号:13页码:8702-8709
ISSN号0022-3263
DOI10.1021/acs.joc.9b00756
通讯作者Shen, Jingshan(shenjingshan@simm.ac.cn) ; Aisa, Haji A.(haji@ms.xjb.ac.cn)
英文摘要Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.
WOS关键词HANTZSCH 1,4-DIHYDROPYRIDINES ; DERIVATIVES ; IRON ; MILD
资助项目Special Foundation of Chinese Academy of Sciences for strategic pilot technology[XDA12040105]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000474796800033
源URL[http://119.78.100.183/handle/2S10ELR8/289296]  
专题中国科学院上海药物研究所
通讯作者Shen, Jingshan; Aisa, Haji A.
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, South Beijing Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Topharman Shanghai Co Ltd, Bldg 1,388 Jialilue Rd,Zhangjiang Hitech Pk, Shanghai 201209, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Weiming,Sun, Changliang,Zhang, Yan,et al. Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)-ones to Quinolin-2(1H)-ones Using Transition-Metal-Activated Persulfate Salts[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(13):8702-8709.
APA Chen, Weiming.,Sun, Changliang.,Zhang, Yan.,Hu, Tianwen.,Zhu, Fuqiang.,...&Aisa, Haji A..(2019).Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)-ones to Quinolin-2(1H)-ones Using Transition-Metal-Activated Persulfate Salts.JOURNAL OF ORGANIC CHEMISTRY,84(13),8702-8709.
MLA Chen, Weiming,et al."Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)-ones to Quinolin-2(1H)-ones Using Transition-Metal-Activated Persulfate Salts".JOURNAL OF ORGANIC CHEMISTRY 84.13(2019):8702-8709.

入库方式： OAI收割

来源：上海药物研究所

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