中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The MYC Paralog-PARP1 Axis as a Potential TherapeuticTarget in MYC Paralog-Activated Small Cell Lung Cancer

文献类型:期刊论文

作者Bian, Xing1,2,3,4; Wang, Xiaolin1,2,3,4; Zhang, Qiuyan5; Ma, Liying1,2,3,4; Cao, Guozhen1,2,3,4; Xu, Ao6,7; Han, Jinhua8,9; Huang, Jun8,9; Lin, Wenchu1,3,4
刊名FRONTIERS IN ONCOLOGY
出版日期2020-10-08
卷号10
ISSN号2234-943X
关键词small cell lung cancer MYCparalog PARP1 BET DNA damage response
DOI10.3389/fonc.2020.565820
通讯作者Lin, Wenchu(wenchu@hmfl.ac.cn)
英文摘要Poly (ADP-ribose) polymerase 1 (PARP1) is highly expressed in small cell lung cancer (SCLC) and has emerged as an attractive target for treatment of SCLC. However, the clinical significance of PARP1 expression in SCLC remains elusive. In this study, we showed that high PARP1 expression was associated with better overall survival (OS), and was positively correlated with the expression of MYC paralogs in patients with SCLC. We demonstrated that PARP1 was transcriptionally regulated by MYC paralogs. Integrative analysis of multiple RNA-seq data sets indicated that DNA damage response (DDR) genes involved in the replication stress response (RSR) and homologous recombination (HR) repair pathways were highly enriched in MYC paralog-addicted SCLC cell models and in human SCLC specimens. Targeting the MYC paralog-PARP1 axis with concomitant BET and PARP inhibition resulted in synergistic effects in MYC paralog-activated SCLC. Our study identified a critical PARP1 regulatory pathway, and provided evidence for a rational combination treatment strategy for MYC paralog-activated SCLC.
WOS关键词PARP INHIBITORS ; DNA ; PATHWAY ; GENE ; MUTATIONS ; TARGETS ; STRESS ; DRIVEN
资助项目National Natural Science Foundation of China[81972191] ; National Natural Science Foundation of China[81672647] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences[KFJ-STS-SCYD-010] ; Science and Technology Major Project of Anhui Province[18030801140] ; Key program of 13th five-year plan of CASHIPS[KP-2017-26] ; 100-Talent Program of Chinese Academy of Sciences
WOS研究方向Oncology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000580545700001
资助机构National Natural Science Foundation of China ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Key program of 13th five-year plan of CASHIPS ; 100-Talent Program of Chinese Academy of Sciences
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/104633]  
专题中国科学院合肥物质科学研究院
通讯作者Lin, Wenchu
作者单位1.Chinese Acad Sci, High Field Magnet Lab, Hefei, Peoples R China
2.Univ Sci & Technol China, Hefei, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Peoples R China
4.High Magnet Field Lab Anhui Prov, Hefei, Peoples R China
5.Univ Sci & Technol China, Sch Life Sci, Innovat Ctr Cell Signaling Network, CAS Key Lab Innate Immun & Chron Dis, Hefei, Peoples R China
6.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp 1, Hefei, Peoples R China
7.Anhui Prov Hosp, Dept Pathol, Hefei, Peoples R China
8.Zhejiang Univ, MOE Key Lab Biosyst Homeostasis & Protect, Hangzhou, Peoples R China
9.Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714
Bian, Xing,Wang, Xiaolin,Zhang, Qiuyan,et al. The MYC Paralog-PARP1 Axis as a Potential TherapeuticTarget in MYC Paralog-Activated Small Cell Lung Cancer[J]. FRONTIERS IN ONCOLOGY,2020,10.
APA Bian, Xing.,Wang, Xiaolin.,Zhang, Qiuyan.,Ma, Liying.,Cao, Guozhen.,...&Lin, Wenchu.(2020).The MYC Paralog-PARP1 Axis as a Potential TherapeuticTarget in MYC Paralog-Activated Small Cell Lung Cancer.FRONTIERS IN ONCOLOGY,10.
MLA Bian, Xing,et al."The MYC Paralog-PARP1 Axis as a Potential TherapeuticTarget in MYC Paralog-Activated Small Cell Lung Cancer".FRONTIERS IN ONCOLOGY 10(2020).

入库方式: OAI收割

来源:合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。