An Efficient and Scalable Synthesis of Hydroxyglimepiride and Carboxyl Glimepiride: Main Metabolites of Glimepiride
文献类型：期刊论文
| 作者 | Khakimov, Makhmudjon1,2; Jiang, Xiangrui2 ; Yang, Feipu2; Shen, Jingshan2
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| 刊名 | INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
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| 出版日期 | 2022-10-01 |
| 卷号 | 32期号:4页码:417-421 |
| ISSN号 | 0971-1627 |
| 通讯作者 | Yang, Feipu(yangfeipu@simm.ac.cn) |
| 英文摘要 | A facile and scalable synthetic route for preparing metabolites of glimepiride is disclosed here. Starting from commercially available materials 4 and 6, hydroxyglimepiride (2) and carboxyl glimepiride (3) were synthesized on a gram scale with 64% and 67% overall yields, respectively, in a four-step sequence. N, N'-carbonyldiimidazole, and NaBH 4 were used in the reduction of carboxyl glimepiride (3) to hydroxyglimepiride (2), which makes the process safer and more convenient. Besides, excellent purity of product (99.34%) was achieved without purification over column chromatography. |
| 资助项目 | Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120225005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000911427900001 |
| 出版者 | CONNECT JOURNALS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303672]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Feipu |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Laboratmy Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Khakimov, Makhmudjon,Jiang, Xiangrui,Yang, Feipu,et al. An Efficient and Scalable Synthesis of Hydroxyglimepiride and Carboxyl Glimepiride: Main Metabolites of Glimepiride[J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY,2022,32(4):417-421. |
| APA | Khakimov, Makhmudjon,Jiang, Xiangrui,Yang, Feipu,&Shen, Jingshan.(2022).An Efficient and Scalable Synthesis of Hydroxyglimepiride and Carboxyl Glimepiride: Main Metabolites of Glimepiride.INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY,32(4),417-421. |
| MLA | Khakimov, Makhmudjon,et al."An Efficient and Scalable Synthesis of Hydroxyglimepiride and Carboxyl Glimepiride: Main Metabolites of Glimepiride".INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 32.4(2022):417-421. |
入库方式： OAI收割
来源：上海药物研究所
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