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Facile Synthesis of Benzimidazoles via N-Arylamidoxime Cyclization

文献类型：期刊论文

作者Qin, Hongjian2; Odilov, Abdullajon2,3; Bonku, Emmanuel Mintah2,3; Zhu, Fuqiang4; Hu, Tianwen4; Liu, He4; Aisa, Haji A.1; Shen, Jingshan1,2,3
刊名ACS OMEGA
出版日期2022-12-02
页码10
ISSN号2470-1343
DOI10.1021/acsomega.2c06554
通讯作者Aisa, Haji A.(haji@ms.xjb.ac.cn) ; Shen, Jingshan(shenjingshan@simm.ac.cn)
英文摘要A facile synthesis of benzimidazoles was described by a one-pot process containing acylation-cyclization of Narylamidoxime. This method provided an alternative synthesis of benzimidazoles with a certain diversity of substituted groups in acceptable yields (up to 96%). More importantly, the construction of bis-benzimidazole (8), the key intermediate for making telmisartan, was achieved by adopting this method that enabled avoiding the undesired nitration with nitric/sulfuric acid and the cyclization in polyphosphoric acid in the existing operations.
WOS关键词COPPER-CATALYZED SYNTHESIS ; II RECEPTOR ANTAGONISTS ; ONE-POT PREPARATION ; 2-SUBSTITUTED BENZIMIDAZOLES ; BIOLOGICAL-ACTIVITY ; TELMISARTAN ; 2-NITROANILINES ; DERIVATIVES ; EFFICIENT ; CHLORIDE
资助项目West Light Foundation of The Chinese Academy of Sciences[2018-XBYJRC-001] ; ANSO Collaborative Research Project[ANSO-CR-SP-2020-03]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000892822900001
源URL[http://119.78.100.183/handle/2S10ELR8/304321]  
专题中国科学院上海药物研究所
通讯作者Aisa, Haji A.; Shen, Jingshan
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Topharman Shanghai Co Ltd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Qin, Hongjian,Odilov, Abdullajon,Bonku, Emmanuel Mintah,et al. Facile Synthesis of Benzimidazoles via N-Arylamidoxime Cyclization[J]. ACS OMEGA,2022:10.
APA Qin, Hongjian.,Odilov, Abdullajon.,Bonku, Emmanuel Mintah.,Zhu, Fuqiang.,Hu, Tianwen.,...&Shen, Jingshan.(2022).Facile Synthesis of Benzimidazoles via N-Arylamidoxime Cyclization.ACS OMEGA,10.
MLA Qin, Hongjian,et al."Facile Synthesis of Benzimidazoles via N-Arylamidoxime Cyclization".ACS OMEGA (2022):10.

入库方式： OAI收割

来源：上海药物研究所

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