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A review of the synthetic strategies toward the antiviral drug tecovirimat

文献类型：期刊论文

作者Bonku, Emmanuel Mintah3,4; Qin, Hongjian2,3,4; Odilov, Abdullajon3,4; Abduahadi, Safomuddin3,4; Guma, Samuel Desta3,4; Zhu, Fuqiang1; Shen, Jingshan3,4
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
出版日期2024-09-19
页码16
ISSN号1477-0520
DOI10.1039/d4ob01092b
英文摘要This review provides a comprehensive analysis of synthetic routes for tecovirimat, an antiviral drug used to treat orthopoxvirus infections, including monkeypox and smallpox. We focus on the scale-up synthesis of key intermediates, including cycloheptatriene, as documented in the published literature and patent records. The review highlights the efficiency, yield, and purity of these approaches, as well as the minimization of genotoxic and in-process impurities. Furthermore, we critically evaluate the recently reported optimized industrial-scale synthesis process, highlighting its advantages and limitations, and identifying avenues for further improvement. By obtaining insights from the published literature and patent records, this review elucidates the current state of knowledge regarding key synthesis parameters influencing tecovirimat production and emphasizes the critical importance of optimizing synthesis techniques to achieve remarkable improvements in safety and environmental impact. This review serves as a valuable resource for researchers and industry professionals in the field of R&D and production of APIs, particularly in expediting the safe and efficient industrial production of tecovirimat. Synthesis approaches for tecovirimat API, highlighting pros and cons, summarizing processes for key intermediates, including cycloheptatriene, and evaluating feasibility, efficiency, and environmental sustainability.
WOS关键词INTRAMOLECULAR BUCHNER REACTION ; CYCLOADDITION REACTIONS ; CYCLOHEPTATRIENE ; NORCARADIENE ; ISOMERIZATION ; PYROLYSIS ; COMPLEXES ; MECHANISM
资助项目Chinese Academy of Sciences[CASIMM120234003] ; Institute of Drug Innovation of the Chinese Academy of Sciences[2020YFE0205600] ; China-Uzbekistan New Drug, Belt and Road Joint Laboratory Construction and Innovative Drug Research for National Key R&D Program of China ; University of Chinese Academy of Sciences (UCAS)
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001319669500001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/313663]  
专题新药研究国家重点实验室
通讯作者Zhu, Fuqiang; Shen, Jingshan
作者单位1.Topharman Shanghai Co Ltd, 388 Jialilue Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Bonku, Emmanuel Mintah,Qin, Hongjian,Odilov, Abdullajon,et al. A review of the synthetic strategies toward the antiviral drug tecovirimat[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2024:16.
APA Bonku, Emmanuel Mintah.,Qin, Hongjian.,Odilov, Abdullajon.,Abduahadi, Safomuddin.,Guma, Samuel Desta.,...&Shen, Jingshan.(2024).A review of the synthetic strategies toward the antiviral drug tecovirimat.ORGANIC & BIOMOLECULAR CHEMISTRY,16.
MLA Bonku, Emmanuel Mintah,et al."A review of the synthetic strategies toward the antiviral drug tecovirimat".ORGANIC & BIOMOLECULAR CHEMISTRY (2024):16.

入库方式： OAI收割

来源：上海药物研究所

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