An Efficient Asymmetric Synthesis of Finerenone via Evans' Chiral Auxiliary
文献类型：期刊论文
| 作者 | Abduahadi, Safomuddin1,3; Mintah Bonku, Emmanuel3; Zhu, Fuqiang2; Yang, Feipu3; Desta Guma, Samuel1,3; Nuriddinov, Zayniddin1,3; Qin, Hongjian2; Shen, Jingshan1,3 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2025-08-28 |
| 卷号 | 28期号:32页码:6 |
| 关键词 | asymmetric synthesis Evans' chiral auxiliary finerenone transamidations |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.202500538 |
| 英文摘要 | This article reports a new application of Evans' chiral auxiliary for an efficient asymmetric synthesis of finerenone. This new application successfully achieves the key step of stereoselective construction of the naphthyridine core of finerenone, with a high diastereomeric ratio (dr 86:14) and an 80% yield of the desired product via Evans' chiral (R)-4-benzyl-2-oxazolidinone. The downstream transamidation of ethyl ester, with ammonia, leads to the formation of finerenone. |
| WOS关键词 | REDUCTION |
| 资助项目 | University of Chinese Academy of Sciences (UCAS) ; UCAS Scholarship for International Students |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001548457500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321279]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Qin, Hongjian; Shen, Jingshan |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Topharman Shanghai Co Ltd, 388 Jialilue Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Abduahadi, Safomuddin,Mintah Bonku, Emmanuel,Zhu, Fuqiang,et al. An Efficient Asymmetric Synthesis of Finerenone via Evans' Chiral Auxiliary[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2025,28(32):6. |
| APA | Abduahadi, Safomuddin.,Mintah Bonku, Emmanuel.,Zhu, Fuqiang.,Yang, Feipu.,Desta Guma, Samuel.,...&Shen, Jingshan.(2025).An Efficient Asymmetric Synthesis of Finerenone via Evans' Chiral Auxiliary.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,28(32),6. |
| MLA | Abduahadi, Safomuddin,et al."An Efficient Asymmetric Synthesis of Finerenone via Evans' Chiral Auxiliary".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 28.32(2025):6. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。