机构

• 上海药物研究所 [15]
• 上海营养与健康研究所 [1]

采集方式

• OAI收割 [16]

内容类型

• 期刊论文 [16]

发表日期

• 2023 [4]
• 2022 [1]
• 2021 [2]
• 2020 [4]
• 2019 [2]
• 2018 [1]
• 更多

学科主题

• Oncology [1]
• Research &... [1]

筛选

浏览/检索结果: 共16条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19 作者:  Wang, Pingyuan;  Zhu, Wen-Ting;  Wang, Yajing;  Song, Shan-Shan;  Xi, Yong   |  收藏  |  浏览/下载：59/0  |  提交时间：2023/10/17 PARP1 inhibitor  Synthetic lethality  Drug resistance  Anticancer  Structure -activity relationship   YCH1899, a Highly Effective Phthalazin-1(2H)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 20 作者:  Sun, Yuting;  Yang, Hui;  Yuan, Jiaqi;  Wang, Limin;  Song, Shanshan   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17 Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance 期刊论文  OAI收割 EMBO MOLECULAR MEDICINE, 2023, 页码: 24 作者:  Wang, Li-Min;  Wang, Pingyuan;  Chen, Xiao-Min;  Yang, Hui;  Song, Shan-Shan   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/04/10 homologous recombination repair  olaparib-resistant  PARP inhibitor  PARP7  type I interferons   Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割 JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162 作者:  Lai, Mengzhen;  Zhang, Tao;  Chen, Hao;  Song, Peiran;  Tong, Linjiang   |  收藏  |  浏览/下载：111/0  |  提交时间：2023/04/10 fourth-generation EGFR inhibitor  EGFRC797S mutation  NSCLC  drug resistance  small molecular inhibitor   Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion 期刊论文  OAI收割 CANCER BIOLOGY & THERAPY, 2022, 页码: 14 作者:  Guo, Ne;  Li, Meng-Zhu;  Wang, Li-Min;  Chen, Hua-Dong;  Song, Shan-Shan   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15 Combination therapy  PARP1  resistance  CXCL3-ERK1/2 signaling  migration and invasion   Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer 期刊论文  OAI收割 CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18 作者:  Zhang, Ning;  Tian, Yu-Nan;  Zhou, Li-Na;  Li, Meng-Zhu;  Chen, Hua-Dong   |  收藏  |  浏览/下载：29/0  |  提交时间：2021/05/24 Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer 期刊论文  OAI收割 Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1 作者:  Ning Zhang;  Yu-Nan Tian;  Li-Na Zhou;  Meng-Zhu Li;  Hua-Dong Chen   |  收藏  |  浏览/下载：16/0  |  提交时间：2021/12/01 Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422 作者:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang   |  收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01 B cell receptor  Bruton's tyrosine kinase  ibrutinib  small-molecule inhibitor  B cell malignancies   Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter 期刊论文  OAI收割 CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 1, 页码: 12 作者:  Tian, Yu-Nan;  Chen, Hua-Dong;  Tian, Chang-Qing;  Wang, Ying-Qing;  Miao, Ze-Hong   |  收藏  |  浏览/下载：12/0  |  提交时间：2020/12/24 Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors 期刊论文  OAI收割 AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+ 作者:  Chen, Hua-Dong;  Guo, Ne;  Song, Shan-Shan;  Chen, Chuan-Huizi;  Miao, Ze-Hong   |  收藏  |  浏览/下载：22/0  |  提交时间：2020/12/24 PARP inhibitors resistance  BRCA2  COX-2  BIRC3  apoptotic resistance