中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [7]
采集方式
OAI收割 [7]
内容类型
期刊论文 [7]
发表日期
2020 [2]
2019 [2]
2017 [2]
2013 [1]
学科主题
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Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
OAI收割
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
OAI收割
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
  |  
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 714-727
作者:
Chen, Hua-Dong
;
Chen, Chuan-Huizi
;
Wang, Yu-Ting
;
Guo, Ne
;
Tian, Yu-Nan
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/21
PARP1 inhibitor
PARP1-DNA binding
PARP1-DNA trapping
poly(ADP-ribose) polymerase activity
cytotoxicity
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity
期刊论文
OAI收割
CANCER RESEARCH, 2019, 卷号: 79, 期号: 13, 页码: 2
作者:
Chen, Hua-Dong
;
Chen, Chuan-Huizi
;
Wang, Yu-Ting
;
Guo, Ne
;
Tian, Yu-Nan
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
OAI收割
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
OAI收割
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality
Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 7, 页码: 2885-2903
作者:
Ye, Na
;
Chen, Chuan-Huizi
;
Chen, TianTian
;
Song, Zilan
;
He, Jin-Xue
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08