机构

• 上海药物研究所 [20]
• 化学研究所 [1]
• 昆明植物研究所 [1]

采集方式

• OAI收割 [22]

内容类型

• 期刊论文 [22]

发表日期

• 2022 [1]
• 2019 [3]
• 2018 [1]
• 2017 [2]
• 2016 [1]
• 2014 [1]
• 更多

学科主题

• Biochemist... [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共22条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial 期刊论文  OAI收割 CELL METABOLISM, 2022, 卷号: 34, 期号: 5, 页码: 667-+ 作者:  Wang, Jiang;  Zhao, Jing;  Yan, Cong;  Xi, Cong;  Wu, Chenglin   |  收藏  |  浏览/下载：28/0  |  提交时间：2022/08/16 Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230 作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang   |  收藏  |  浏览/下载：43/0  |  提交时间：2020/07/01 PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster   Green and Facile Assembly of Diverse Fused N-Heterocycles Using Gold-Catalyzed Cascade Reactions in Water 期刊论文  OAI收割 MOLECULES, 2019, 卷号: 24, 期号: 5, 页码: 30 作者:  Jia, Xiuwen;  Li, Pinyi;  Liu, Xiaoyan;  Lin, Jiafu;  Chu, Yiwen   |  收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 amine nucleophiles  alkynoic acids  cascade reaction  gold catalysis  fused N-heterocycles   designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia 期刊论文  OAI收割 actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216 作者:  Wu Chenglin;  Xi Cong;  Tong Junhua;  Zhao Jing;  Jiang Hualiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2020/07/01 DOPAMINE D-1  BERBERINE  EXPRESSION  INHIBITORS  IDENTIFICATION  CHOLESTEROL  MUTATIONS  LDLR  PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster   Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK) 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027 作者:  Gu, Zhanni;  Wu, Lingyan;  Duan, Yanan;  Wang, Jiang;  Zhou, Shengbin   |  收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Adenosine 5 '-monophosphate-activated protein kinase  AMPK activators  Berberine  Tetrahydroberberine  T2DM   Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464 作者:  Zhou, Shengbin;  Duan, Yanan;  Wang, Jiang;  Zhang, Jin;  Sun, Haifeng   |  收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Tetrahydroberberine  4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines  Mitochondrial respiration  AMPK indirect activators  db/db mice   Separation of the potential G-quadruplex ligands from the butanol extract of Zanthoxylum ailanthoides Sieb. & Zucc. by countercurrent chromatography and preparative high performance liquid chromatography 期刊论文  OAI收割 JOURNAL OF CHROMATOGRAPHY A, 2017, 卷号: 1507, 页码: 104-114 作者:  Han, Tian;  Cao, Xueli;  Xu, Jing;  Pei, Hairun;  Zhang, Hong   |  收藏  |  浏览/下载：19/0  |  提交时间：2018/04/11 Zanthoxylum Ailanthoides Sieb. & Zucc  Anti-tumor Activity  G-quadruplex Ligands  Alkaloids  Ph-zone Refining Counter Current Chromatography (Ccc)   Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective alpha(1A)-Adrenoceptor Antagonists 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 20, 页码: 9489-9502 作者:  Guo, Diliang;  Li, Jing;  Lin, Henry;  Zhou, Yu;  Chen, Ying   |  收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D-1, D-2 and serotonin 5-HT1A multiple action profiles 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 21, 页码: 5838-5846 作者:  Li, Zeng;  Huang, Jiye;  Sun, Haifeng;  Zhou, Shengbin;  Guo, Lin   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 l-SPD  Tetrahydroprotoberberine  Dopamine receptor  Serotonin receptor  Multiple action   Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D-1, D-2 and serotonin 5-HT1A multi-action profile 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 4, 页码: 856-868 作者:  Sun, Haifeng;  Zhu, Liyuan;  Yang, Huicui;  Qian, Wangke;  Guo, Lin   |  收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Asymmetric synthesis  Tetrahydroprotoberberines  Dopamine receptors  Serotonin receptors  Multi-action  New pharmacological profile