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浏览/检索结果: 共204条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism 期刊论文  OAI收割 NATURE REVIEWS ENDOCRINOLOGY, 2024, 页码: 17 作者:  Duan, Jia;  He, Xin-Heng;  Li, Shu-Jie;  Xu, H. Eric   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/07 Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins 期刊论文  OAI收割 CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 13 作者:  Cong, Zhaotong;  Zhao, Fenghui;  Li, Yang;  Luo, Gan;  Mai, Yiting   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/03/13 Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs 期刊论文  OAI收割 SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6, 页码: 11 作者:  Wang, James Jiqi;  Jin, Sanshan;  Zhang, Heng;  Xu, Youwei;  Hu, Wen   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/05/07 Self-supervised noise modeling and sparsity guided electron tomography volumetric image denoising 期刊论文  OAI收割 ULTRAMICROSCOPY, 2024, 卷号: 255, 页码: 11 作者:  Yang, Zhidong;  Zang, Dawei;  Li, Hongjia;  Zhang, Zhao;  Zhang, Fa   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/20 Electron tomography  Image denoising  Self-supervised learning   Ligand activation mechanisms of human KCNQ2 channel 期刊论文  OAI收割 Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632 作者:  Ma, Demin;  Zheng, Yueming;  Li, Xiaoxiao;  Zhou, Xiaoyu   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/03/26 The cryo-EM data were collected at the Advanced Center for Electron Microscopy at the Shanghai Institute of Materia Medica, the Chinese Academy of Sciences (CAS). This work was supported by the CAS Strategic Priority Research Program (XDB37030103 to H.E.X. 项目  OAI收割 资助机构: The cryo-EM data were collected at the Advanced Center for Electron Microscopy at the Shanghai Institute of Materia Medica, the Chinese Academy of Sciences (CAS). This work was supported by the CAS Strategic Priority Research Program (XDB37030103 to H.E.X., 2023- -   |  收藏  |  浏览/下载：0/0  |  提交时间：2023/12/08 Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者:  Zhou, Qingtong;  Liu, Xiao;  Neri, Dario;  Li, Wenxin;  Favalli, Nicholas   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/12/08 phosphoinositide 3-kinase  drug target  ligand  binding pocket  chemical scaffold   Structural analysis of the dual agonism at GLP-1R and GCGR 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 33, 页码: 12 作者:  Li, Yang;  Zhou, Qingtong;  Dai, Antao;  Zhao, Fenghui;  Chang, Rulue   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/05/07 glucagon-like peptide-1 receptor  glucagon receptor  cryo-electron microscopy  dual agonism   cryo-EM data were collected at the Cryo-Electron Microscopy Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 项目  OAI收割 资助机构: cryo-EM data were collected at the Cryo-Electron Microscopy Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 2023- -   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/05/07 Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors 期刊论文  OAI收割 CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 15 作者:  Feng, Wenbo;  Zhou, Qingtong;  Chen, Xianyue;  Dai, Antao;  Cai, Xiaoqing   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17