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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [72]
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OAI收割 [81]
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期刊论文 [79]
会议论文 [2]
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Exploration of the potential association between GLP-1 receptor agonists and suicidal or self-injurious behaviors: a pharmacovigilance study based on the FDA Adverse Event Reporting System database
期刊论文
OAI收割
BMC MEDICINE, 2024, 卷号: 22, 期号: 1, 页码: 13
作者:
Zhou, Jianxing
;
Zheng, You
;
Xu, Baohua
;
Long, Songjun
;
Zhu, Li-e
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/25
GLP-1RAs
Suicidal or self-injurious behaviors
Pharmacovigilance
FAERS database
Type 2 diabetes
Obesity
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G
s
proteins
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 13
作者:
Cong, Zhaotong
;
Zhao, Fenghui
;
Li, Yang
;
Luo, Gan
;
Mai, Yiting
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/13
Conserved class B GPCR activation by a biased intracellular agonist
期刊论文
OAI收割
NATURE, 2023, 页码: 25
作者:
Zhao, Li-Hua
;
He, Qian
;
Yuan, Qingning
;
Gu, Yimin
;
He, Xinheng
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23
作者:
Chen, Lili
;
Yun, Ying
;
Guo, Shimeng
;
Wang, Xiaoyan
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 16
作者:
Yan, Ying
;
Niu, Zhoumin
;
Sun, Chao
;
Li, Peng
;
Shen, Siyi
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/12/13
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119
期刊论文
OAI收割
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2022, 页码: 29
作者:
Xu, Peiyu
;
Huang, Sijie
;
Guo, Shimeng
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/09/30
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
Darbalaei, Sanaz
;
Chang, Ru-lue
;
Zhou, Qing-tong
;
Chen, Yan
;
Dai, An-tao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
glucagon receptor
dual and triple agonist
cAMP
pERK1/2
unimolecular polypharmacology
Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists
期刊论文
OAI收割
PHARMACEUTICALS, 2022, 卷号: 15
作者:
Sun, Lei
;
Zheng, Zhi-Ming
;
Shao, Chang-Sheng
;
Zhang, Zhi-Yong
;
Li, Ming-Wei
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/12/22
glucagon-like peptide-1
GLP-1 receptor agonist
functional protein design
molecular dynamics simulation
long-acting antihyperglycemic
Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 20, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Qingtong
;
Li, Yang
;
Chen, Li-Nan
;
Zhang, Zi-Chen
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
type 2 diabetes mellitus
cryoelectron microscopy
peptidomimetic agonism
Modulating effects of RAMPs on signaling profiles of the glucagon receptor family
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 2, 页码: 637-650
作者:
Shao, Lijun
;
Chen, Yan
;
Zhang, Shikai
;
Zhang, Zhihui
;
Cao, Yongbing
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/06/15
G protein-coupled receptor
Glucagon receptor family
Receptor activity-modulating protein
Signaling
Allosteric modulation
GPCR-RAMP interaction
Receptor pharmacology
Ligand selectivity