中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [131]
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期刊论文 [498]
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Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 20
作者:
Zheng, Fuqiang
;
Hu, Zhengtao
;
Chen, Hai
;
Cheng, Jiaxin
;
Hou, Qiongqiong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/06/23
Heterocycle-fused phenylcyclohexylamines
Multi-target antagonists
NMDAR
Monoamine transporter
Antidepressants
Enhanced Bioactivity of Natural Products by Halogenation: A Database Survey and Quantum Chemistry Calculation Study
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 10486-10496
作者:
Cao, Ruini
;
Li, Jintian
;
Liao, Qingyi
;
Shao, Mei
;
Zhang, Qian
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/07/25
Discovery of multi-chitinase inhibitors cinnamyl thiazolidinone compounds as candidates for insect growth regulators via ligand-based optimization strategies
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 306, 页码: 14
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Fu, Haoyu
;
Li, Yan
;
Zou, Renxuan
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/05/27
Multi-chitinase inhibitor
Cinnamaldehyde compounds
Thiazolidinone compounds
Ligand-based optimization
Insect growth regulators (IGRs)
Anterior anchor placement in deltoid ligament augmentation for the treatment of ankle fracture with both syndesmosis and deltoid ligament injury: A biomechanical study
期刊论文
OAI收割
JOURNAL OF ORTHOPAEDIC SURGERY, 2025, 卷号: 33, 期号: 2, 页码: 7
作者:
Fei, Han
;
Li, Yu
;
Li, Ting
;
Li, Changrun
;
Fu, Gang
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/18
biomechanics
deltoid ligament
syndesmosis
trauma
Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 卷号: 73, 期号: 19, 页码: 11998-12013
作者:
Zhu, Ziwei
;
Li, Huilin
;
Zhu, Wenya
;
Du, Shaoqing
;
Yang, Zhaokai
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/06/23
odorant-binding proteins
jasmone derivatives
rational design
aphid repellents
insect behaviorregulators
Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors
期刊论文
OAI收割
COMMUNICATIONS CHEMISTRY, 2025, 卷号: 8, 期号: 1, 页码: 13
作者:
Gulyas, Kinga Virag
;
Zhou, Liping
;
Salamonsen, Daniel
;
Prester, Andreas
;
Bartels, Kim
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/06/23
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
;
Sun, Donglin
;
Yang, Zhuo
;
Wang, Qi
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/05/27
Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11
作者:
Tang, Bixi
;
Xie, Like
;
Wang, Yangyang
;
Shi, Yulong
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/11/26
Lung first-pass effect
Tanreqing injection
Pharmacokinetics
Sepsis-associated acute lung injury
Acute respiratory distress syndrome
B(MIDA)-directed site-selective intermolecular halofluoroalkylation of alkenes: synthesis of diversely functionalized building blocks
期刊论文
OAI收割
CHEMICAL SCIENCE, 2025, 页码: 8
作者:
Wu, Hengbo
;
Luo, Ruitong
;
Peng, Jingjing
;
Han, Zijian
;
Zhang, Renjie
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/04/01
F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 13
作者:
Zhang, Qian
  |  
收藏
  |  
浏览/下载:28/0
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提交时间:2025/02/28