中国科学院机构知识库网格
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Pharmacokinetics, mass balance, and metabolism of [
14
C]PLB1004, a selective and irreversible EGFR-TKI in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 14
作者:
Liu, Donghui
;
Li, Qian
;
Yan, Shu
;
Zhang, Xinyue
;
Li, Weiqiang
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2025/04/01
PLB1004
[C-14]PLB1004
Radioactivity
Mass balance
EGFR-TKI
Leveraging Landsat and Google Earth Engine for long-term chlorophyll-a monitoring: A case study of Lake Balaton's water quality
期刊论文
OAI收割
ECOLOGICAL INFORMATICS, 2025, 卷号: 90, 页码: 103245
作者:
Li, Huan
;
Somogyi, Boglarka
;
Chen, Xiaona
;
Luo, Zengliang
;
Blix, Katalin
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/07/18
Water quality
Remote sensing
Oversampling imbalanced dataset
Machine learning
Applicability of Landsat
Integrating temporal information
Pharmacokinetics, mass balance, and metabolism of [
14
C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 12
作者:
Gao, Lei
;
Ma, Sheng
;
Yan, Shu
;
Zhang, Hua
;
Tian, Ling
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/07/25
FCN-437c
CDK4/6 inhibitor
Mass balance
Radiopharmacokinetics
Drug metabolism
Microplastics decrease soil compressibility but have no major impact on soil physical properties
期刊论文
OAI收割
SOIL & TILLAGE RESEARCH, 2025, 卷号: 253, 页码: 106688
作者:
Dong, Yuhao
;
Ren, Lidong
;
Jia, Xiaoxu
;
Liao, Xiaoyong
;
Huang, Laiming
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/18
Uniaxial compression test
Microplastic shapes
Soil structure
Soil compaction
X-ray micro-CT
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Structural optimization of phthalazine derivatives for anti-HBV activities to improve oral bioavailability
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 10
作者:
Yang, Yurong
;
Xiao, Fuling
;
Zuo, Jianping
;
Yang, Li
;
Hu, Youhong
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
HBV
Capsid assembly modulators
Structural optimization
Oxidative metabolism
Kadcoccinoids A-K, triterpenoids from
Kadsura coccinea
with PCSK9 expression inhibitory activities
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 238, 页码: 13
作者:
Duan, Yelin
;
Chen, Tong
;
Guo, Pengju
;
Li, Chenyue
;
Chen, Yihan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Kadsura coccinea
Schisandraceae
Lanostane-type triterpenoids
Protostane-type triterpenoids
PCSK9
Pantelignans A-F, benzofuran sesquineolignan racemates from the roots and rhizomes of
Pandanus
tectorius:
isolation, chiral resolution, and configurational assignment
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1338, 页码: 8
作者:
Huang, Yuepei
;
Chen, Jieting
;
Liu, Zhilong
;
Peng, Lihua
;
Qiao, Weilin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2025/06/23
Pandanus tectorius
Benzofuran sesquineolignans
Enantiomers
ECD calculations
Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Sesquiterpenes with anti-inflammatory activity from the stems and branches of
Melicope patulinervia
期刊论文
OAI收割
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2025, 卷号: 27, 期号: 7, 页码: 977-982
作者:
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Melicope patulinervia
Rutaceae
zierane-type sesquiterpenes
guaiane-type sesquiterpenes
anti-inflammation