中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
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Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9
作者:
Li, Linquan
;
Gu, Xi
;
Meng, Jingyi
;
Wen, Yiming
;
Yi, Jing
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
p53 Y220C
Synthesis
Structural modification
Drug design
Numerical investigation on helium pressurization behavior of cryogenic propellant in microgravity
期刊论文
OAI收割
APPLIED THERMAL ENGINEERING, 2025, 卷号: 269
作者:
Guo, Songyuan
;
Jiang, Zan
;
Li, Jianqiang
;
Xu, Pengli
;
Zhuan, Rui
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/07/21
Cryogenic propellant
Microgravity
Pressurization
Species transfer
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
期刊论文
OAI收割
NATURE CANCER, 2025, 页码: 37
作者:
Wang, Hanling
;
Zhang, Sulin
;
Pan, Qiang
;
Guo, Jiacheng
;
Li, Ni
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21
作者:
Sui, Qibang
;
Zhou, Yuanyang
;
Li, Manjia
;
Wang, Dan
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/12/25
Synthetic lethal
MSI tumors
WRN inhibitors
Triazolo-pyrimidine derivatives
Reproductive and germ-cell mutagenic effects of poly-and perfluoroalkyl substances (PFAS) to Caenorhabditis elegans after multigenerational exposure
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 卷号: 954
作者:
Cao, Zhenxiao
;
Dai, Linglong
;
Li, Jiali
;
Zhang, Jingyi
;
Wang, Xialian
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/11/20
PFAS
Multigenerational exposure
Caenorhabditis elegans
Germ cell mutagenicity
Whole genome sequencing
Research on the viscoelastic scCO 2 foam systems synergistically stabilized by nonionic/zwitterionic mixed surfactants
期刊论文
OAI收割
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2024, 卷号: 697, 页码: 14
作者:
Zheng, Nanxin
;
Zhu, Jingyi
;
Yang, Zhaozhong
;
Li, Xiaogang
;
Li, Qi
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收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/06/27
ScCO2 foam fluid
Synergistic effect
Wormlike micelles
Foam stabilization mechanism
Microstructure
Reciprocal relationships among parental psychological control, emotion regulation ability, and subjective well-being of adolescents: Disentangling between- and within-person effects
期刊论文
OAI收割
JOURNAL OF AFFECTIVE DISORDERS, 2024, 卷号: 361, 页码: 546-555
作者:
Deng, Chaoqiong
;
Li, Dongping
;
Li, Yang
;
Liu, Yuxiao
;
Zhang, Jingyi
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/08/12
Parental psychological control
Subjective well-being
Emotion regulation ability
Adolescents
Random intercept cross-lagged panel model
Stillbirths Associated with Particle Pollution are Disproportionally Contributed by Sand Dust: Findings from 52 Low- and Middle-Income Countries
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2024, 卷号: 58, 期号: 36, 页码: 15971-15983
作者:
Li, Pengfei
;
Wu, Jingyi
;
Tong, Mingkun
;
Wang, Ruohan
;
Tang, Mingjin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/10/10
particulate matter
sand dust
stillbirth
joint exposure-response function
maternal health
health inequality
The Reservoir Injury Rules of Water Injection to an Ultralow Permeability Reservoir: Experimental Research Based on Core-NMR and Microfluidic Technology
期刊论文
OAI收割
ENERGY & FUELS, 2024, 卷号: 38, 期号: 16, 页码: 15131-15146
作者:
Zhu, Jingyi
;
Tang, Xinyu
;
Li, Xiaogang
;
Wen, Yiping
;
Deng, Zhiying
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/27