中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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浏览/检索结果: 共161条,第1-10条 帮助

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Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation 期刊论文  OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 159, 页码: 14
作者:  
Sun, Zhiqiang;  Zang, Qinru;  Xu, Chenglong;  Zhang, Xuewen;  Kang, Zhenghui
  |  收藏  |  浏览/下载:4/0  |  提交时间:2025/05/27
A practical synthesis of YZD-7082B, a novel orally bioavailable selective estrogen receptor degrader (SERD) for the treatment of ER plus breast cancer 期刊论文  OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 12
作者:  
He, Yongqi;  Leng, Xin-Yu;  Wang, Runying;  Sun, Lulu;  Zhang, Dan
  |  收藏  |  浏览/下载:0/0  |  提交时间:2025/05/27
Discovery of Thiochroman Derivatives as Potent, Oral Selective Estrogen Receptor Degraders and Antagonists for the Treatment of Endocrine-Resistant Breast Cancer 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 23, 页码: 21545-21567
作者:  
Zhang, Dan;  Lu, Zhengyu;  He, Yongqi;  Leng, Xin-Yu;  Meng, Xin
  |  收藏  |  浏览/下载:19/0  |  提交时间:2025/01/06
Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:  
Liu, Fangjun;  Kou, Qunhuan;  Li, Hongyuan;  Cao, Yangzhi;  Chen, Meng
  |  收藏  |  浏览/下载:17/0  |  提交时间:2024/05/22
Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 25
作者:  
Zhang, Yinyong;  Zhang, Dan;  Zhao, Wenhao;  Li, Hongyuan;  Lu, Zhengyu
  |  收藏  |  浏览/下载:25/0  |  提交时间:2024/05/22
Design, Synthesis, and Anti-tuberculosis Activity of Streptomycin Derivatives 期刊论文  OAI收割
LETTERS IN DRUG DESIGN & DISCOVERY, 2024, 卷号: 21, 期号: 4, 页码: 738-748
作者:  
Zhang, Yinyong;  Zhao, Wenhao;  Yang, Yushe;  Zhou, Xianli;  Guo, Bin
  |  收藏  |  浏览/下载:24/0  |  提交时间:2024/03/06
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9972-9991
作者:  
Wang, Ao;  Luo, Xianggang;  Meng, Xin;  Lu, Zhengyu;  Chen, Kaixian
  |  收藏  |  浏览/下载:16/0  |  提交时间:2023/10/17
Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP 期刊论文  OAI收割
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023, 页码: 12
作者:  
Zhang, Yinyong;  Yang, Yushe;  Meng, Xin;  Zhou, Xianli;  Guo, Bin
  |  收藏  |  浏览/下载:29/0  |  提交时间:2023/04/10
Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 22
作者:  
Wang, Ao;  Luo, Xianggang;  Wang, Yawan;  Meng, Xin;  Lu, Zhengyu
  |  收藏  |  浏览/下载:46/0  |  提交时间:2022/11/11
Design, Synthesis, and Structure-Activity Relationship Studies of Bisamide Derivatives of Amphotericin B with Potent Efficacy and Low Toxicity 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 17
作者:  
Ma, Huijun
  |  收藏  |  浏览/下载:28/0  |  提交时间:2023/04/10