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中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [76]
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期刊论文 [156]
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Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 20
作者:
Zheng, Fuqiang
;
Hu, Zhengtao
;
Chen, Hai
;
Cheng, Jiaxin
;
Hou, Qiongqiong
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收藏
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浏览/下载:0/0
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提交时间:2025/06/23
Heterocycle-fused phenylcyclohexylamines
Multi-target antagonists
NMDAR
Monoamine transporter
Antidepressants
Structural optimization and discovery of high effective isopropanolamine-based TPS1 inhibitors as promising broad-spectrum fungicide candidates
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 290, 页码: 17
作者:
Jiang, Zhiyang
;
Wang, Na
;
Chen, Jinxiu
;
Xu, Huan
;
Zhu, Wenya
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浏览/下载:0/0
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提交时间:2025/05/27
Trehalose-6-phosphate synthase
Structural optimization
Isopropanolamine compounds
Inhibitors
Fungicide candidates
Discovery of multi-chitinase inhibitors cinnamyl thiazolidinone compounds as candidates for insect growth regulators via ligand-based optimization strategies
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 306, 页码: 14
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Fu, Haoyu
;
Li, Yan
;
Zou, Renxuan
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浏览/下载:0/0
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提交时间:2025/05/27
Multi-chitinase inhibitor
Cinnamaldehyde compounds
Thiazolidinone compounds
Ligand-based optimization
Insect growth regulators (IGRs)
Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 卷号: 73, 期号: 19, 页码: 11998-12013
作者:
Zhu, Ziwei
;
Li, Huilin
;
Zhu, Wenya
;
Du, Shaoqing
;
Yang, Zhaokai
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浏览/下载:0/0
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提交时间:2025/06/23
odorant-binding proteins
jasmone derivatives
rational design
aphid repellents
insect behaviorregulators
Design, Synthesis, and Biological Evaluation of Peptidomimetic Tetrahydropyrrole Spirodihydroindolones as SARS-CoV-2 3CL Protease Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 16, 期号: 5, 页码: 790-796
作者:
Hu, Liuyan
;
Zhao, Zhi
;
Zhang, Shujing
;
Yang, Lei
;
Cui, Wenjie
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收藏
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浏览/下载:0/0
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提交时间:2025/06/23
COVID-19
SARS-CoV-2
3CL protease
Peptidomimetic inhibitors
Tetrahydropyrrole spirodihydroindolone
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
;
Sun, Donglin
;
Yang, Zhuo
;
Wang, Qi
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浏览/下载:0/0
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提交时间:2025/05/27
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2025, 页码: 13
作者:
Chen, Jinxiu
;
Shi, Dongmei
;
Jiang, Zhiyang
;
Zou, Renxuan
;
Zhang, Jingyu
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收藏
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浏览/下载:7/0
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提交时间:2025/04/01
O. furnacalis
Chitinase
5-alkenylthiazolidinone
1,4-benzodioxane
Dual-chitinases inhibitor
Novel 5-alkenylthiothiazolidinone scaffold discovery as Multi-Chitinases inhibitors to arrest the molting of Asian corn borer
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1321, 页码: 11
作者:
Shi, Dongmei
;
Ji, Xinge
;
Zou, Renxuan
;
Jiang, Zhiyang
;
Duan, Yangwei
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收藏
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浏览/下载:17/0
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提交时间:2024/10/21
5-alkenylthiothiazolidinone scaffold
Multichitinase inhibitor
Amide bond
Asian corn borer
insect growth regulator
Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 22
作者:
Guma, Samuel Desta
;
Zhou, Zhaoyin
;
Song, Kang
;
Yang, Feipu
;
Suo, Jin
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收藏
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浏览/下载:14/0
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提交时间:2024/12/11
SARS-CoV-2
3CL pro inhibitors
Peptidomimetics
Spiropyrrolidine derivatives
Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5235-5248
作者:
Wang, Yingying
;
Zhang, Youping
;
Luo, Hao
;
Wei, Wei
;
Liu, Wanting
|
收藏
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浏览/下载:18/0
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提交时间:2025/04/01
Ubiquitin-specific protease 2
KRAS
Gambogic acid
Multiple myeloma
Degradation
Ubiquitination
Allosteric pocket
Deubiquitination
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