机构

• 上海药物研究所 [68]
• 深圳先进技术研究院 [1]

采集方式

• OAI收割 [69]

内容类型

• 期刊论文 [50]
• 会议论文 [15]
• 专利 [3]
• 学位论文 [1]

发表日期

• 2025 [3]
• 2024 [1]
• 2023 [3]
• 2022 [3]
• 2021 [1]
• 2020 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共69条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d] pyrimidines as potent HPK1 kinase inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 119, 页码: 13 作者:  Wu, Feifei;  Li, Huiyu;  Li, Weiqiang;  Zhang, Laishun;  An, Qi   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/04/01 Optimization  Hematopoietic progenitor kinase 1  Inhibitor  Cancer immunotherapy   Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 18 作者:  He, Jie;  Ma, Xiaoyu;  Sun, Jia;  Chen, Manman;  Xu, Lan   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 25 作者:  Lu, Yuhang;  Yan, Ziqin;  Sun, Jiaqi;  Wang, Chenxu;  Xu, Lan   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 5, 页码: 3986-4006 作者:  Sun, Yaoliang;  Chen, Manman;  Han, Yuyan;  Li, Weiqiang;  Ma, Xiaoyu   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/05/07 Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1H)-one Focused DNA-Encoded Library 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15 作者:  Wen, Xin;  Zhang, Minmin;  Duan, Zhiqiang;  Suo, Yanrui;  Lu, Weiwei   |  收藏  |  浏览/下载：47/0  |  提交时间：2023/10/17 Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15 作者:  Wu, Feifei;  Li, Huiyu   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17 Hematopoietic progenitor kinase 1 (HPK1)  Cancer immunotherapy  Inhibitor  T cell   Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 153 作者:  Zhang, Xu;  Wang, Yuxiang;  Zhang, Xi;  Shen, Yanyan;  Yang, Kang   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/03/27 Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3K alpha inhibitors in oesophageal squamous cell carcinoma 期刊论文  OAI收割 CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 卷号: 12, 期号: 5, 页码: 17 作者:  Xing, Hui;  Gao, Mengshi;  Wang, Yuxiang;  Zhang, Xu;  Shi, Jiajie   |  收藏  |  浏览/下载：53/0  |  提交时间：2022/08/16 CDKNIA  cell cycle  CRISPR-SAM  CYH33  ESCC  EZH2  PI3K alpha inhibitor  resistance   Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 3, 页码: 1054-1067 作者:  Zhang, Xu;  Wang, Yuxiang;  Meng, Linghua   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/06/15 Esophageal cancer  Esophageal squamous cell carcinoma  Esophageal adenocarcinoma  Next-generation sequencing  Genomic alteration  Somatic mutation  Copy number variation  Molecularly targeted therapy   SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lymphoma 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 1, 页码: 209 作者:  Zhang Xi;  Duan Yuting;  Wang Yi;  Zhao Xingdong;  Sun Yiming   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/05/22 PI3K6  PI3K/AKT/mTOR  diffuse large B-cell lymphoma  resistance  combination therapy