机构

• 上海药物研究所 [18]
• 金属研究所 [2]
• 深圳先进技术研究院 [1]

采集方式

• OAI收割 [21]

内容类型

• 期刊论文 [21]

发表日期

• 2024 [1]
• 2022 [2]
• 2021 [3]
• 2020 [2]
• 2019 [3]
• 2017 [2]
• 更多

学科主题

• Multidisci... [1]

筛选

浏览/检索结果: 共21条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：47/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15 作者:  Zhan, Zhengsheng;  Ji, Yinchun;  Su, Haixia;  Fang, Chen;  Peng, Xia   |  收藏  |  浏览/下载：51/0  |  提交时间：2023/04/10 Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation 期刊论文  OAI收割 CELL DISCOVERY, 2022, 卷号: 8, 期号: 1, 页码: 17 作者:  Xie, Zuoquan;  Wang, Zhen;  Fan, Fengying;  Zhou, Jinpei;  Hu, Zhaoxue   |  收藏  |  浏览/下载：37/0  |  提交时间：2023/04/10 Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18 作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng   |  收藏  |  浏览/下载：49/0  |  提交时间：2021/08/17 Axl  Cancer  Inhibitor  Pyrrolo[2,3-d]pyrimidine   Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207 作者:  Du, Daohai;  Xu, Dandan;  Zhu, Licheng;  Stazi, Giulia;  Zwergel, Clemens   |  收藏  |  浏览/下载：97/0  |  提交时间：2021/08/17 Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 7, 页码: 3956-3975 作者:  Zhang, Hefeng;  Peng, Xia;  Dai, Yang;  Shao, Jingwei;  Ji, Yinchun   |  收藏  |  浏览/下载：28/0  |  提交时间：2021/06/11 DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation 期刊论文  OAI收割 BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69 作者:  Lv, Jianlu;  Wang, Wei;  Zhu, Xialin;  Xu, Xiaoju;  Yan, Qiuying   |  收藏  |  浏览/下载：42/0  |  提交时间：2020/12/21 Alzheimer'sdisease  Microglia  AMPK alpha 1  DW14006  Phagocytosis  Neuro-inflammation   DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice 期刊论文  OAI收割 DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988 作者:  Xu, Xu;  Wang, Wei;  Wang, Zhengyu;  Lv, Jianlu;  Xu, Xiaoju   |  收藏  |  浏览/下载：43/0  |  提交时间：2020/12/24 fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85 作者:  Zhan, Wenhu;  Che, Jinxin;  Xu, Lei;  Wu, Yizhe;  Hu, Xiaobei   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01 Pyrazole-thiophene derivatives  Akt inhibitor  Antitumor   Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288 作者:  Dong, Xiaowu;  Zhan, Wenhu;  Zhao, Mengting;  Che, Jinxin;  Dai, Xiaoyang   |  收藏  |  浏览/下载：38/0  |  提交时间：2020/07/01