中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
期刊论文
OAI收割
JOURNAL OF SPORT AND HEALTH SCIENCE, 2025, 卷号: 14, 页码: 23
作者:
Guo, Mingwei
;
Shen, Fei
;
Guo, Xiaozhen
;
Zhang, Jun
;
Ma, Ying
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2025/04/01
Daily variance
Circadian
Muscle strength
Metabolic benefits
Resistance exercise
A biomimetic aluminum composite exhibiting gradient-distributed thermal expansion, high thermal conductivity, and highly directional toughness
期刊论文
OAI收割
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2025, 卷号: 213
作者:
Dong, B. Ke
;
Wei, C. Long
;
Lin, J. Chao
;
Xie, L. Lu
;
Liu, K. Ke
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2024/11/20
Biomimetic materials
Gradient materials
Low thermal expansion
High thermal conductivity
Toughness
IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 19
作者:
Yao, Mingyue
;
Yan, Wenzhong
;
Wang, Yafang
;
Zhao, Yu
;
Xu, Xiaowei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/04/01
Acute myeloid leukemia
HDAC inhibitor
FLT3-ITD mutation
DNA damage response
Synergistic effect
Drug resistance
Glycyrrhizic acid and patchouli alcohol in Huoxiang Zhengqi attenuate intestinal inflammation and barrier injury via regulating endogenous corticosterone metabolism mediated by 11β-HSD1
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 338, 页码: 17
作者:
Wang, Yangyang
;
Sun, Chuying
;
Cao, Yutang
;
Jiao, Tingying
;
Wang, Kanglong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/12/16
Huoxiang Zhengqi
Glycyrrhizic acid
Patchouli alcohol
Inflammation
Intestinal barrier injury
11 beta-hydroxysteroid dehydrogenase 1
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 14
作者:
Chen, Yu-jun
;
Zhao, Yu
;
Yao, Ming-yue
;
Wang, Ya-fang
;
Ma, Ming
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
acute myeloid leukemia
FLT3
p300/CBP
quizartinib resistance
combination strategy
Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR
期刊论文
OAI收割
CELL DISCOVERY, 2025, 卷号: 11, 期号: 1, 页码: 4
作者:
Luo, Ping
;
Xin, Wenwen
;
Guo, Shimeng
;
Li, Xin
;
Zhang, Qing
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/04/01
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress
期刊论文
OAI收割
CELL METABOLISM, 2025, 卷号: 37, 期号: 1, 页码: 104-+
作者:
Song, Lintao
;
Hou, Yushu
;
Xu, Da
;
Dai, Xijia
;
Luo, Jianya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity and Overcomes Resistance in KRAS-Mutant Tumors and BCR-ABL-Positive Leukemia
期刊论文
OAI收割
CANCER RESEARCH, 2025, 卷号: 85, 期号: 1, 页码: 101-117
作者:
Luo, Ziwei
;
Lin, Chencen
;
Yu, Chuwei
;
Yuan, Changxian
;
Wu, Wenyong
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/02/28
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Formation mechanism of climate warming-induced landslides in permafrost along the Qinghai-Tibet Engineering corridor
期刊论文
OAI收割
FRONTIERS IN EARTH SCIENCE, 2024, 卷号: 12, 页码: 14
作者:
Wei, Tao
;
Wang, Jiao
;
Xie, Ming
;
Feng, Peihua
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/01/24
climate warming
permafrost degradation
landslides
Qinghai-Tibet Engineering corridor
Qinghai-Tibet plateau