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浏览/检索结果: 共236条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11 作者:  Guma, Samuel Desta;  Song, Kang;  Sun, Haiguo   |  收藏  |  浏览/下载：49/0  |  提交时间：2025/08/20 SARS-CoV-2  3CL(pro) inhibitors  Thioamide derivatives  Spiropyrrolidine derivatives  Nirmatrelvir  HCoV-OC43  Antiviral  Metabolic stability   Structure and function of a huge photosystem I-fucoxanthin chlorophyll supercomplex from a coccolithophore 期刊论文  OAI收割 SCIENCE, 2025, 卷号: 389, 期号: 6765, 页码: 10 作者:  Shen, Lili;  Ren, Fei;  Wang, Yin-Chu;  Li, Zhenhua;  Zheng, Mengyuan   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/11/03 The Intermediate-mass Black Hole Reverberation Mapping Project: First Detection of Mid-infrared Lags in Prototypical Intermediate-mass Black Holes in NGC 4395 and POX 52 期刊论文  OAI收割 ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 989, 期号: 2 作者:  Sun, Jingbo;  Guo, Hengxiao;  Zuo, Wenwen;  Lira, Paulina;  Gu, Minfeng   |  收藏  |  浏览/下载：63/0  |  提交时间：2025/08/25 NMRExtractor: leveraging large language models to construct an experimental NMR database from open-source scientific publications 期刊论文  OAI收割 CHEMICAL SCIENCE, 2025, 卷号: 16, 期号: 25, 页码: 11548-11558 作者:  Wang, Qinggong;  Zhang, Wei;  Chen, Mingan;  Li, Xutong;  Xiong, Zhaoping   |  收藏  |  浏览/下载：16/0  |  提交时间：2025/08/20 Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors 期刊论文  OAI收割 SCIENCE TRANSLATIONAL MEDICINE, 2025, 卷号: 17, 期号: 801, 页码: 18 作者:  Yang, Ruirui;  Wang, Bei;  Su, Zhaoming;  Song, Ying;  Zhang, Yingying   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/08/20 Discovery of novel antimyeloma agents targeting TRIP13 by molecular modeling and bioassay 期刊论文  OAI收割 RSC MEDICINAL CHEMISTRY, 2025, 页码: 14 作者:  Bunu, Samuel Jacob;  Cai, Haiyan;  Zhou, Zhaoyin;  Zhang, Yanlei;  Lai, Yue   |  收藏  |  浏览/下载：26/0  |  提交时间：2025/06/23 Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14 作者:  Wu, Xinyuan;  Li, Shunyao;  Liang, Ting;  Yu, Qing;  Zhang, Yiwei   |  收藏  |  浏览/下载：39/0  |  提交时间：2025/06/23 Activity-based protein profiling data  Covalent DNA-encoded chemical library  Covalent ligand selection  Lysine-targeting covalent inhibitors   Visible-light-mediated site-selective C(sp2)-H alkylation of tropones facilitates semi-synthesis of cephafortunoids A and B 期刊论文  OAI收割 CHEMICAL SCIENCE, 2025, 页码: 9 作者:  Zeng, Qi-Xiang;  Zheng, Cheng-Yu;  Ge, Zhan-Peng;  Zhao, Jin-Xin;  Yue, Jian-Min   |  收藏  |  浏览/下载：35/0  |  提交时间：2025/06/23 O-Cyanobenzaldehydes Irreversibly Modify Both Buried and Exposed Lysine Residues in Live Cells 期刊论文  OAI收割 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 14, 页码: 11955-11963 作者:     |  收藏  |  浏览/下载：39/0  |  提交时间：2025/05/27 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：52/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy