中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 卷号: 25, 期号: 20, 页码: 13
作者:
Lin, Feifei
;
Hu, Yingchun
;
Zhang, Yifan
;
Zhao, Lijuan
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/26
PBPK modeling
piperine
food-drug interaction
Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study
期刊论文
OAI收割
ANNALS OF MEDICINE, 2023, 卷号: 55, 期号: 2, 页码: 9
作者:
Li, Cuiyun
;
Wu, Min
;
Zhang, Hong
;
Zhu, Xiaoxue
;
Fu, Li
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2024/01/16
Forsythin
pharmacokinetics
safety
tolerability
food effect
Absorption, Distribution, Metabolism, and Excretion of [
14
C]BS1801, a Selenium-Containing Drug Candidate, in Rats
期刊论文
OAI收割
MOLECULES, 2023, 卷号: 28, 期号: 24, 页码: 16
作者:
Yang, Cheng
;
Xue, Mingzhen
;
He, Yifei
;
Yin, Hanwei
;
Yang, Chen
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/01/26
[C-14]BS1801
BS1801 (butaselen)
tissue distribution
metabolism
mass balance
selenium
Conference report for the 10th China Bioanalysis Forum annual meeting
期刊论文
OAI收割
BIOANALYSIS, 2023, 页码: 4
作者:
Dong, Kelly
;
Zhu, Mingshe
;
Tang, Daniel
;
Jin, Fan
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/12/19
China Bioanalysis Forum
CBF
ICH M10
DMPK and Bioanalysis for New Modalities
A validated LC-MS/MS method for the quantification of bevacizumab in rat, cynomolgus monkey, and human serum
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 235, 页码: 11
作者:
Zhou, Ainan
;
Yu, Jinghua
;
Wu, Yali
;
Xue, Hao
;
Zhong, Dafang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/10/17
Monoclonal antibody
Bevacizumab
LC-MS
MS
Surrogate peptide
Pharmacokinetics
Serum
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [
3
H]Catalpol in Rats: the Main Bioactive Component of
Rehmannia glutinosa
for the Treatment of Ischemic Stroke
期刊论文
OAI收割
CURRENT DRUG METABOLISM, 2023, 页码: 10
作者:
  |  
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  |  
浏览/下载:15/0
  |  
提交时间:2023/12/08
[H-3]catalpol
Rehmannia glutinosa
mass balance
tissue distribution
metabolism
intestinal flora
ischemic stroke.
Simultaneous quantification of 3 ',4 '-dimethoxy flavonol-3-O-glucoside and its major metabolite in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 225, 页码: 9
作者:
Wang, Lu
;
Shen, Haifeng
;
Zhan, Yan
;
Zhang, Yifan
;
Zhang, Yong
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2023/04/10
3?4?-Dimethoxy flavonol-3-O-glucoside
Aglycone glucuronide
LC-MS
MS
Human pharmacokinetic study
放射性标记药物在我国新药研发中的应用进展
期刊论文
OAI收割
药学学报, 2023, 卷号: 58, 期号: 2, 页码: 313
作者:
刁星星
;
余京华
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2023/05/22
radiolabeled drug
drug metabolism
mass balance
drug research and development
放射性标记药物
药物代谢
物质平衡
新药研发
Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum AlbuminS
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 1, 页码: 8-16
作者:
Wu, Yali
;
Chen, Lili
;
Chen, Jian
;
Xue, Hao
;
He, Qingfeng
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/27
Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 809-818
作者:
Guo, Zitao
;
Liu, Mengling
;
Meng, Jian
;
Xue, Yaru
;
Huang, Qi
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/08/16