中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海光学精密机械... [100]
上海药物研究所 [44]
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期刊论文 [560]
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Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma
期刊论文
OAI收割
HAEMATOLOGICA, 2024, 卷号: 109, 期号: 4, 页码: 1206-1219
作者:
Chen, Gege
;
Gao, Xuejie
;
Jia, Xinyan
;
Wang, Yingcong
;
Xu, Li
  |  
收藏
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浏览/下载:1/0
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提交时间:2024/05/07
Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 15
作者:
Yan, Xue
;
Zhang, Chun
;
Gao, Li-Xin
;
Liu, Min -Min
;
Yang, Yu-Ting
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
Imidazo[124] triazole derivatives
Fluorescence property
SHP1
Bioactivity
Cellular imaging
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG
期刊论文
OAI收割
BMC BIOLOGY, 2024, 卷号: 22, 期号: 1, 页码: 14
作者:
Liu, Zhipei
;
Wang, Feng
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/13
hERG
K525N
Gating Polarity
Voltage-Sensing Domain
LQT2
Scallop-bacteria symbiosis from the deep sea reveals strong genomic coupling in the absence of cellular integration
期刊论文
OAI收割
ISME JOURNAL, 2024, 卷号: 18, 期号: 1, 页码: 14
作者:
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收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
chemosynthesis
cold seep
ectosymbiosis
glass scallop
thiotrophy
Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:
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收藏
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浏览/下载:9/0
  |  
提交时间:2024/01/26
osimertinib resistance
targeted drug delivery
liposomes
panobinostat
tumor-associated macrophage
combination therapy
Late Mesozoic tectonic evolution and thermal history in the northeast Xing'an Block, NE China: Implications for gold mineralization and preservation
期刊论文
OAI收割
GEOLOGICAL JOURNAL, 2023, 页码: 25
作者:
Wang, Ting
;
Gao, Shen
;
Xu, Hong
;
Qin, Kezhang
;
Wang, Xunlian
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/01/22
(U-Th)/He thermochronology
Ar-Ar dating
Au mineralization and preservation
epithermal
orogenic
U-Pb dating
Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation
期刊论文
OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023, 卷号: 55, 期号: 12, 页码: 1884-1891
作者:
Jin, Shuhan
;
Li, Bo
;
Zhang, Bibo
;
Gao, Xuejie
;
Jia, Xinyan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/27
dihydrocelastrol
multiple myeloma
JAK2/STAT3
PSMB5
bortezomib resistance
AMPK role in epilepsy: a promising therapeutic target?
期刊论文
OAI收割
JOURNAL OF NEUROLOGY, 2023, 页码: 24
作者:
Qi, Yingbei
;
Zhang, Yong-mei
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
AMPK
Epilepsy
Neuron Modulation
Metabolism
Ion Channels
mTOR
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:59/0
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提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
期刊论文
OAI收割
MOLECULAR PSYCHIATRY, 2023, 页码: 11
作者:
Zhang, Yong-mei
;
Zong, Hai-chao
;
Qi, Ying-bei
;
Chang, Liu-liu
;
Gao, Ya-nan
  |  
收藏
  |  
浏览/下载:13/0
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提交时间:2023/12/08