中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
地球环境研究所 [11]
地理科学与资源研究所 [7]
上海药物研究所 [5]
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期刊论文 [67]
会议论文 [2]
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地球科学::地质学 [3]
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Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16
作者:
Nie, Hui-Jun
;
Li, Ben-Fu
;
Sun, Jingya
;
Yuan, Yali
;
Zhang, Zhi-Gao
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/26
Triple-negative breast cancer
Targeting transcription regulation
Orally bioavailable degrader
PROTAC
Cyclin-dependent Kinase 9
Real-world emission characteristics of VOCs from typical cargo ships and their potential contributions to secondary organic aerosol and O
3
under low-sulfur fuel policies
期刊论文
OAI收割
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2024, 卷号: 24, 期号: 16, 页码: 8999-9017
作者:
Zhang, Fan
;
Xiao, Binyu
;
Liu, Zeyu
;
Zhang, Yan
;
Tian, Chongguo
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/10/24
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 12, 页码: 10035-10056
作者:
Wang, Wen-Jing
;
Gao, Lixin
;
Wang, Simei
;
Huang, Wensi
;
Meng, Xin-Yu
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/08/20
A validated LC-MS/MS method for the quantitation of daratumumab in rat serum using rapid tryptic digestion without IgG purification and reduction
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8
作者:
Li, Weiqiang
;
Huang, Wensi
;
Yu, Xiong
;
Chen, Chong
;
Yuan, Yali
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/05/22
Daratumumab
LC-MS/MS
Surrogate peptide
Pharmacokinetics
Leveraging Joint-Action Embedding in Multiagent Reinforcement Learning for Cooperative Games
期刊论文
OAI收割
IEEE TRANSACTIONS ON GAMES, 2024, 卷号: 16, 期号: 2, 页码: 470-482
作者:
Lou, Xingzhou
;
Zhang, Junge
;
Du, Yali
;
Yu, Chao
;
He, Zhaofeng
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/09/09
Games
Predictive models
Reinforcement learning
Convergence
Task analysis
Correlation
Training
Joint-action embedding
multiagent
policy gradient
reinforcement learning
Soil moisture decline in China's monsoon loess critical zone: More a result of land- use conversion than climate change
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 15, 页码: 8
作者:
  |  
收藏
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浏览/下载:24/0
  |  
提交时间:2024/05/27
water
afforestation
deep soil
the Loess Plateau
monsoon climate
First Nonhuman Primate-Sized Magnetic Particle Imaging System Based on Digital-Scanned Focus Field
期刊论文
OAI收割
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 2024, 卷号: 73, 页码: 11
作者:
Wei, Zechen
;
Liu, Yanjun
;
Liu, Sijia
;
Yu, Xiaomei
;
Zhang, Haoran
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/09/09
Coils
Imaging
Three-dimensional displays
Magnetic fields
Sensitivity
Spatial resolution
Permanent magnets
Digital scanned
focus field
magnetic particle imaging (MPI)
nonhuman primate (NHP)
Ni5P4-NiP2-Ni2P Nanocomposites Tangled with N-Doped Carbon for Enhanced Electrochemical Hydrogen Evolution in Acidic and Alkaline Solutions
期刊论文
OAI收割
CATALYSTS, 2022, 卷号: 12, 期号: 12, 页码: 15
作者:
Pei, Miaomiao
;
Song, Xiaowei
;
Zhong, Haihong
;
Estudillo-Wong, Luis Alberto
;
Gao, Yingchun
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2023/02/24
three-component nickel phosphides
N-doped carbon nanotubes
hydrogen evolution reaction
mesoporous carbon network
synergistic effect
A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 11
作者:
Zeng, Yue
;
Shi, Wei
  |  
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2022/08/30
Acyl Transfer
Anti-Tumor
One-Step Synthesis
Site-Specific ADCs
Thioester
Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 809-818
作者:
Guo, Zitao
;
Liu, Mengling
;
Meng, Jian
;
Xue, Yaru
;
Huang, Qi
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/08/16