中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [20]
上海硅酸盐研究所 [7]
化学研究所 [5]
合肥物质科学研究院 [3]
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期刊论文 [63]
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GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model
期刊论文
OAI收割
CELL RESEARCH, 2024, 页码: 16
作者:
Yang, Xiaodong
;
Liu, Guole
;
Feng, Guihai
;
Bu, Dechao
;
Wang, Pengfei
  |  
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2024/12/06
Characterization and noncovalent inhibition of the K63-deubiquitinase activity of SARS-cov-2 PLpro
期刊论文
OAI收割
ANTIVIRAL RESEARCH, 2024, 卷号: 228, 页码: 12
作者:
Liu, Xin
;
Zheng, Miao
;
Zhang, Hongqing
;
Feng, Bo
;
Li, Jiaqi
  |  
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2024/10/21
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9972-9991
作者:
Wang, Ao
;
Luo, Xianggang
;
Meng, Xin
;
Lu, Zhengyu
;
Chen, Kaixian
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
Cryo-EM structures of orphan GPR21 signaling complexes
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1
作者:
Xi Lin
;
Bo Chen
;
Yiran Wu
;
Yingqi Han
;
Ao Qi
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/05/22
Multi-omics analysis reveals the pathogenesis of db/db mice diabetic kidney disease and the treatment mechanisms of multi-bioactive compounds combination from Salvia miltiorrhiza
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 16
作者:
Xu, Zhuo
;
Xiang, Xiang
;
Su, Shulan
;
Zhu, Yue
;
Yan, Hui
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/12/13
multi-bioactive compounds combination
diabetic kidney disease
multi-omics
Salvia miltiorrhiza
PI3K/Akt/FoxO signaling pathways
Delicate fabrication of ZnO/ZnCo2O4 heterojunction HoMSs as anodes for lithium-ion batteries with high rate capability
期刊论文
OAI收割
MATERIALS CHEMISTRY FRONTIERS, 2022, 页码: 11
作者:
Zhang, Hui
;
Zhou, Xin
;
Liu, Yahui
;
Hou, Baoxiu
;
Ma, Linlin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/02/24
Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 22
作者:
Wang, Ao
;
Luo, Xianggang
;
Wang, Yawan
;
Meng, Xin
;
Lu, Zhengyu
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/11/11
A general model for simulating the quench behavior of canted-cosine-theta (CCT) quadrupole magnets
期刊论文
OAI收割
Cryogenics, 2022, 卷号: 128, 页码: 103574
作者:
Kang, Rui
;
Wang, Yingzhe
;
Yang, Huan
;
Zhou, Jin
;
Chen, Xin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/11/10