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上海药物研究所 [293]
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期刊论文 [302]
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Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 19
作者:
Yin, Wen
;
Xu, Heng
;
Bai, Zhonghao
;
Wu, Yue
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 21
作者:
Hu, Hongmei
;
Wang, Qun
;
Yu, Dianping
;
Tao, Xiaoyu
;
Guo, Mengmeng
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/02/28
BMI1
colorectal cancer
CSN5
PD-L1
tumor cell senescence
Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5286-5304
作者:
Gao, Ruiyang
;
Yue, Bei
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
Irinotecan
Intestinal mucositis
b-Glucuronidase
Enterococcus faecalis
Intestinal stem cells
Epithelial regeneration
bacteria-host irinotecan axis
Dehydrodiisoeugenol
Palladium-Catalyzed Directing-Group-Mediated
γ
-C(
sp
3
)-H Glycosylation for Synthesis of
C
-Alkyl Glycosides
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2024, 页码: 9
作者:
Zhong, Qiuyu
;
Yu, Changyue
;
Wang, Jinlin
;
Wang, Jiang
;
Chen, Kaixian
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/11/26
C-alkyl glycosides
Glycosylation
Pd-catalyzed
Amino acid
gamma-C(sp(3))-H functionalization
Chemoproteomics of Marine Natural Product Naamidine J Unveils CSE1L as a Therapeutic Target in Acute Lung Injury
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14
作者:
Gao, Cheng-Long
;
Song, Jin-Qian
;
Yang, Ze-Nan
;
Wang, Haojie
;
Wu, Xin-Yuan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/11/05
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 13
作者:
Zhang, Zemin
;
Li, Yuanqing
;
Yang, Jie
;
Li, Jiacheng
;
Lin, Xiongqiang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/09/26
Rh(III)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 8, 页码: 8
作者:
Hu, Shulei
;
Zhang, Yu
;
Xie, Xiong
;
Li, Luhan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/05
C -H functionalization
Rh(III)-catalyzed
Alkenylation
Cyclic peptides
Macrolactamization
Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 14, 页码: 12184-12204
作者:
Zhou, Zhenfei
;
Huang, Siqi
;
Fan, Shijie
;
Li, Xueyuan
;
Wang, Chengyu
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/08/22
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 6, 页码: 4855-4869
作者:
Gu, Chenming
;
Liu, Jiayuan
;
Qian, Fei
;
Yu, Wenchao
;
Huang, Doudou
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/05/07
Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 2, 页码: 623-634
作者:
Xiong, Jiacheng
;
Cui, Rongrong
;
Li, Zhaojun
;
Zhang, Wei
;
Zhang, Runze
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/05/07
Drug metabolism
Aldehyde oxidase
Transfer learning
Graph neural network
Kinase inhibitor