中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [170]
深圳先进技术研究院 [13]
大连化学物理研究所 [12]
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期刊论文 [241]
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Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma
期刊论文
OAI收割
HAEMATOLOGICA, 2024, 卷号: 109, 期号: 4, 页码: 1206-1219
作者:
Chen, Gege
;
Gao, Xuejie
;
Jia, Xinyan
;
Wang, Yingcong
;
Xu, Li
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 卷号: 127, 页码: 14
作者:
Zhang, Hui
;
Hu, Ke
;
Lu, Yumeng
;
Xu, Zhijian
;
Chen, Gege
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/25
Multiple myeloma
M1 macrophages
Th1 cells
Immunomodulatory
Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation
期刊论文
OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023, 卷号: 55, 期号: 12, 页码: 1884-1891
作者:
Jin, Shuhan
;
Li, Bo
;
Zhang, Bibo
;
Gao, Xuejie
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/27
dihydrocelastrol
multiple myeloma
JAK2/STAT3
PSMB5
bortezomib resistance
The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13-MAPK-YWHAE signaling pathway
期刊论文
OAI收割
JOURNAL OF TRANSLATIONAL MEDICINE, 2023, 卷号: 21, 期号: 1, 页码: 17
作者:
Wang, Yingcong
;
Dong, Sanfeng
;
Hu, Ke
;
Xu, Li
;
Feng, Qilin
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/01/26
Norcantharidin
Derivative
DCZ5417
TRIP13
Anti-myeloma
MAPK
Discovery of zolinium TSG1180 as a novel agonist of transgelin-2 for treating asthma
期刊论文
OAI收割
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, 卷号: 167, 页码: 115556
作者:
Yuan, Hong-Kai
;
Li, Bo
;
Wu, Leyun
;
Wang, Xue-Ling
;
Lv, Zhi-Ying
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/26
Active learning
Consensus labelling
Eye irritation
Serious eye damage
Structural alerts
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 91, 页码: 11
作者:
Zhao, Yitian
;
Zhang, Min
;
Hou, Xudong
;
Han, Jiaxin
;
Qin, Xiaoya
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Salicylanilide
hPL inhibitor
Structure -activity relationship
Anti -obesity
ETCM v2.0: An update with comprehensive resource and rich annotations for traditional Chinese medicine
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 6, 页码: 2559-2571
作者:
Zhang, Yanqiong
;
Li, Xin
;
Shi, Yulong
;
Chen, Tong
;
Xu, Zhijian
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
Traditional Chinese medicine
Database
Target identification
Network visualization
New drug research and development
Molecular mechanism
Quality marker
Drug repurposing
Ligand-induced activation and G protein coupling of prostaglandin F-2 alpha receptor
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 11
作者:
Wu, Canrong
;
Xu, Youwei
;
He, Qian
;
Li, Dianrong
;
Duan, Jia
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/10/17
Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma
期刊论文
OAI收割
LEUKEMIA, 2023, 页码: 4
作者:
Xu, Li
;
Wang, Yingcong
;
Wang, Guanli
;
Guo, Shushan
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17