中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [94]
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期刊论文 [367]
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From Hit to Lead: Discovery of Novel Selective RIPK1 Inhibitor with Pyridoimidazole Scaffold for the Treatment of Autoimmune Diseases through Phenotypic Screening and Structural Optimization
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 69, 期号: 3, 页码: 3252-3288
作者:
Wan, Jihong
;
Xiong, Xiao-Yu
;
Geng, Zixiang
;
Yuan, Benjun
;
Ma, Youzhen
  |  
收藏
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浏览/下载:0/0
  |  
提交时间:2026/04/01
Nitrogen transformation and N2O production pathways under arsenic and cadmium stress in Chongming Island, China
期刊论文
OAI收割
MARINE POLLUTION BULLETIN, 2025, 卷号: 221, 页码: 118485
作者:
Jiang, Yinghui
;
Yin, Guoyu
;
Nie, Minghua
;
Yan, Caixia
;
Ding, Mingjun
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/09/22
Nitrogen transformation
N2O production pathways
Heavy metal(loid)
Chongming Island
The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα
期刊论文
OAI收割
CELL METABOLISM, 2025, 卷号: 37, 期号: 11, 页码: 2149-2166
作者:
Xie, Zhifu
;
Cheng, Long
;
Hu, Yue
;
Song, Gaolei
;
Wang, Fan
  |  
收藏
  |  
浏览/下载:0/0
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提交时间:2026/01/28
The interplay between tissue-resident microbiome and host proteins by integrated multi-omics during progression of colorectal adenoma to carcinoma
期刊论文
OAI收割
IMETA, 2025, 页码: 37
作者:
Wu, Di
;
Wang, An-Jun
  |  
收藏
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浏览/下载:0/0
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提交时间:2025/12/03
colorectal cancer
metagenomics
microbiota-host interaction
proteomics
tissue-resident microbiome
Engineering small-molecule phototheranostics for infectious disease imaging and therapy in NIR-II
期刊论文
OAI收割
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2025, 卷号: 192, 页码: 27
作者:
Ding, Qihang
;
Zhang, Yifan
;
Fan, Xianrun
;
Zhu, Liming
;
Han, Linli
  |  
收藏
  |  
浏览/下载:0/0
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提交时间:2025/12/04
Infectious diseases
NIR-II
Molecular imaging
Phototheranostics
Small molecules
Bile Acid-based Microcapsule-Like Cocrystals of Phytosterols with Enhanced Solubility, Bioavailability, and Bioactivity
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2025, 页码: 13
作者:
Tang, Lei
;
Feng, Yinan
;
Bian, Yifei
;
Sun, Zhixiong
;
Ding, Qiaoce
  |  
收藏
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浏览/下载:0/0
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提交时间:2025/12/04
pharmaceutical cocrystal
phytosterols
solubility
bioavailability
lipid-lowering
PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment
期刊论文
OAI收割
SCIENCE CHINA-CHEMISTRY, 2025, 页码: 32
作者:
Ding, Qihang
;
Luo, Yi
;
Wu, Hao
;
Tao, Jing
;
Zhang, Yibin
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收藏
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浏览/下载:0/0
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提交时间:2025/12/04
inflammatory bowel disease
PLGA
nanomedicine
diagnosis
drug delivery
Discovery of Novel Tridentate Alkenyl Diacid Derivatives as Potent ATP Citrate Lyase Inhibitors for the Treatment of Hepatocellular Carcinoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 15, 页码: 15598-15616
作者:
Yang, Yurou
;
Zhai, Jimao
;
Wang, Fan
;
Song, Gaolei
;
Xu, Honghong
  |  
收藏
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浏览/下载:0/0
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提交时间:2025/09/09
D-glucuronyl C5-Epimerase Binds to EGFR to Suppress Kidney Fibrosis
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 13
作者:
Jing, Xiaoqi
;
Wu, Jun
;
Ning, Jingru
;
Ding, Xiaoyu
;
Du, Zhenyun
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
epidermal growth factor receptor
epithelial-to-mesenchymal transition
glucuronyl C5-epimerase
kidney fibrosis
Green synthesis of 2-trifluoromethylquinoline skeletons
via
organocatalytic
N
-[(
α
-trifluoromethyl)vinyl]isatins CN bond activation
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2025, 卷号: 36, 期号: 7, 页码: 10
作者:
Ji, Cong-Bin
;
Xie, Ding-Xiong
;
Chen, Mei
;
Lan, Ye-Ying
;
Zhang, Bao-Hua
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2025/07/25
N-[(alpha-Trifluoromethyl)vinyl]isatins
Pfitzinger-type reaction
C-N bond cleavage
2-CF3-quinoline-4-carboxamide
2-CF3-quinoline-4-carboxylicester