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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [162]
西北高原生物研究所 [36]
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Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of
CCNE1
-Amplified Breast Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:
Wang, Chaofan
;
Fang, Yan
;
Zhou, Ziqin
;
Liu, Zhuoheng
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/09/26
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 17
作者:
Zhang, Tao
;
Pan, Zilu
;
Gao, Jing
;
Wu, Qingqing
;
Bai, Gang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/10/21
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36
作者:
Lou, Jianfeng
;
Zhou, Qianqian
;
Lyu, Xilin
;
Cen, Xinyi
;
Liu, Chen
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
GFPBW1, a β-glucan from
Grifola frondosa
as vaccine adjuvant: APCs activation and maturation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
He, Xiang
;
Lu, Jiang-ling
;
Liao, Wen-feng
;
Long, Yi-ru
;
Zhang, Xing
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/08/20
cancer vaccine
adjuvant
granola frondose polysaccharide
GFPBW1
beta-glucan
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Song, Pei-ran
;
Wan, Zhi-peng
;
Huang, Ge-ge
;
Song, Zi-lan
;
Zhang, Tao
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2024/07/12
diffuse large B-cell lymphoma
BTK inhibitors
drug resistance
BTK C481F
BTK A428D
SYHA1813
A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 8, 页码: 17
作者:
Huang, Yuqing
;
Ning, Yi
;
Chen, Zhiwei
;
Song, Peiran
;
Tang, Haotian
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/31
IRAK4 inhibitor
peritonitis
inflammatory bowel disease (IBD)
macrophage
Introduction and Safe Use of Gas Cylinders in China
期刊论文
OAI收割
ACS Sustainable Chem. Eng., 2024, 卷号: 2024, 期号: 12, 页码: 5496−5508
作者:
Ming-Ming Yu
;
Zhenghao hang Zhang
;
Gui-Ling Guan
;
Bhagyesha Patil
;
Priya Darshini Srinivasan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/23
carbon dioxide
doping
Co-based catalysts
hydrogenation
reaction mechanisms
A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy
期刊论文
OAI收割
CANCER COMMUNICATIONS, 2024, 页码: 5
作者:
Liu, Yingqiang
;
Tong, Linjiang
;
Zhang, Mengge
;
Zhang, Qi
;
Liu, Qiupei
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2024/03/13
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy