机构

• 上海药物研究所 [22]

采集方式

• OAI收割 [22]

内容类型

• 期刊论文 [22]

发表日期

• 2025 [1]
• 2024 [3]
• 2023 [3]
• 2022 [3]
• 2021 [3]
• 2020 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共22条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307 作者:  Sun, Mingyang;  Chen, Beijing;  Teng, Dan;  Zhao, Hongshen;  Liao, Yilie   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21 作者:  Chen, Beijing;  Sun, Mingyang;  Zhang, Chun;  Huang, Qi;  Teng, Dan   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/12/25 Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 17, 页码: 15220-15245 作者:  Saidahmatov, Abdusaid;  Li, Jianan;  Xu, Shihao;  Hu, Xiaobei;  Gao, Xiangqian   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/10/21 Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12735-12759 作者:  Liu, Zhi;  Jiang, Kailong;  Liu, Yan;  Li, Junfei;  Huang, Siqi   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/09/26 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:     |  收藏  |  浏览/下载：21/0  |  提交时间：2024/02/19 Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23 作者:  Li, Xuemei;  Wang, Peipei;  Wang, Chang;  Jin, Tingting;  Xu, Ran   |  收藏  |  浏览/下载：24/0  |  提交时间：2023/10/17 Targeting C/EBP alpha overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18 作者:  Wang, Hanlin;  Luo, Guanghao;  Hu, Xiaobei;  Xu, Gaoya;  Wang, Tao   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia 期刊论文  OAI收割 LEUKEMIA, 2022, 页码: 11 作者:  Jiang, Kailong;  Li, Xuemei;  Wang, Chang;  Hu, Xiaobei;  Wang, Peipei   |  收藏  |  浏览/下载：29/0  |  提交时间：2023/04/10 Design, synthesis, and biological evaluation of Wee1 kinase degraders 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243, 页码: 21 作者:  Zhu, Shulei;  Liu, Jieyu;  Xiao, Donghuai;  Wang, Peipei;  Ma, Jingkun   |  收藏  |  浏览/下载：58/0  |  提交时间：2022/11/11 CRBN  Wee1  PROTAC  Degradation   Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 4, 页码: 3229-3248 作者:  Tong, Lexian;  Wang, Peipei;  Li, Xuemei;  Dong, Xiaowu;  Hu, Xiaobei   |  收藏  |  浏览/下载：28/0  |  提交时间：2022/08/16