中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [53]
青海盐湖研究所 [11]
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期刊论文 [104]
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Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 20
作者:
Zheng, Fuqiang
;
Hu, Zhengtao
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收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/06/23
Heterocycle-fused phenylcyclohexylamines
Multi-target antagonists
NMDAR
Monoamine transporter
Antidepressants
Structural optimization and discovery of high effective isopropanolamine-based TPS1 inhibitors as promising broad-spectrum fungicide candidates
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 290, 页码: 17
作者:
Jiang, Zhiyang
  |  
收藏
  |  
浏览/下载:0/0
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提交时间:2025/05/27
Trehalose-6-phosphate synthase
Structural optimization
Isopropanolamine compounds
Inhibitors
Fungicide candidates
Design, Synthesis, and Biological Evaluation of Peptidomimetic Tetrahydropyrrole Spirodihydroindolones as SARS-CoV-2 3CL Protease Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 16, 期号: 5, 页码: 790-796
作者:
Hu, Liuyan
;
Zhao, Zhi
;
Zhang, Shujing
;
Yang, Lei
;
Cui, Wenjie
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/06/23
COVID-19
SARS-CoV-2
3CL protease
Peptidomimetic inhibitors
Tetrahydropyrrole spirodihydroindolone
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
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收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5235-5248
作者:
Wang, Yingying
;
Zhang, Youping
;
Luo, Hao
;
Wei, Wei
;
Liu, Wanting
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/04/01
Ubiquitin-specific protease 2
KRAS
Gambogic acid
Multiple myeloma
Degradation
Ubiquitination
Allosteric pocket
Deubiquitination
Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 14
作者:
Li, Guanting
;
Hu, Yourong
;
Zhao, Han
;
Peng, Ziyu
;
Shang, Xin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/01/06
benzbromarone
drug-induced liver injury
drug metabolism
obesity
PPAR gamma
AC Losses Properties of Optical Fiber Encapsulated High Temperature Superconducting Conductor on Round Core Cable
期刊论文
OAI收割
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2024, 卷号: 34
作者:
Hu, Zhitao
;
Gao, Shuyang
;
Wang, Ziming
;
Jin, Zhijian
;
Wang, Heng
  |  
收藏
  |  
浏览/下载:7/0
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提交时间:2024/11/20
Conductor on round core cable
magnetization losses
optical fiber encapsulated
transport losses
Conductor on round core cable
magnetization losses
optical fiber encapsulated
transport losses
Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads
期刊论文
OAI收割
COMMUNICATIONS CHEMISTRY, 2024, 卷号: 7, 期号: 1, 页码: 10
作者:
Dong, Sanfeng
;
Huang, Hui
;
Li, Jintian
;
Li, Xiaomei
;
Bunu, Samuel Jacob
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 111, 页码: 16
作者:
Li, Xiaomei
;
Zhang, Hui
;
Dong, Sanfeng
;
Gao, Xuejie
;
Sun, Haiguo
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/09/26
Multiple myeloma
1-amido-2-one-4-thio-deoxypyranose
TRIP13 inhibitor
In vivo activity
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration
期刊论文
OAI收割
ISCIENCE, 2024, 卷号: 27, 期号: 4, 页码: 22
作者:
Li, Hongyi
;
Li, Bei
;
Luo, Wenqi
;
Qi, Xi
;
Hao, You
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/12/06