中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [113]
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Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24
作者:
Li, Na
;
Wang, Linlin
;
Hu, Xinyuan
;
Xu, Haiyan
;
Yang, Bowen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
Influences of synoptic circulations on regional transport, local accumulation and chemical transformation for PM 2.5 heavy pollution over Twain-Hu Basin, central China
期刊论文
OAI收割
JOURNAL OF ENVIRONMENTAL SCIENCES, 2025, 卷号: 154, 页码: 41-51
作者:
Yao, Jingyan
;
Bai, Yongqing
;
Zhao, Tianliang
;
Zhu, Yan
;
Sun, Xiaoyun
  |  
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2025/04/03
Central China
Regional transport
Circulation classification
FLEXPART-WRF
Random Forest
PM 2.5 pollution
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/07/28
Study of ultra-high-energy gamma-ray source 1LHAASO J0056+6346u and its possible origins
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 7
作者:
Cao, Zhen
;
Aharonian, F.
;
Axikegu
;
Bai, Y. X.
;
Bao, Y. W.
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/06/10
gamma rays
cosmic rays
supernova remnant
young massive cluster
pulsar
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XLIV. Integrated NMR/EI-MS/LC-PDA-ESIMS approach for dereplication and targeted isolation of fortunefuroic acids from
Keteleeria
fortunei
across diverse geographical origins
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 235, 页码: 13
作者:
Zhao, Ze-Yu
;
Jiang, Zhe-Lu
;
Tong, Ying-Peng
;
Chi, Chun-Jing
;
Zang, Yi
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/04/24
Keteleeria fortunei
Pinaceae
Geographical origins
Integrated NMR/EI-MS/LC-PDA-ESIMS
methods
Fortunefuroic acids
ATP-Citrate lyase
Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 122, 页码: 19
作者:
Hu, Shulei
;
Zhong, Qiuyu
;
Xie, Xiong
;
Zhang, Shurui
;
Wang, Jinlin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/05/27
Innate immunity response
SARS-CoV-2 3CLpro
PLpro
EV71 3Cpro
2Apro
Viral protease inhibitor
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13
作者:
Li, Kun
;
Zeng, Yue
;
Xiong, Yi-da
;
Wu, Hao-chen
;
Fang, Sui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
drug-target affinity prediction
virtual screening
contrastive learning
graph neural network
N
-methyl-
D
-aspartate (NMDA) receptors
GluN3A subunit.
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 20
作者:
Zhao, Wenfeng
;
Chen, Guofeng
;
He, Jian
;
Shen, Xiaofang
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Development of Orally Bioavailable Octahydroindole-Based Peptidomimetic Derivative as a Broad-Spectrum Inhibitor against HCoV-OC43 and SARS-CoV-2
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 11, 页码: 10823-10844
作者:
Hu, Shulei
;
Zhang, Yumin
;
Wang, Chenchen
;
Li, Jian
;
Su, Haixia
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/07/25
Fluorescence-Coupled Ubiquitination Assay as a High-Throughput Screening Strategy for Novel Cereblon Degraders
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 10111-10127
作者:
Deng, Yanan
;
Yang, Shiling
;
Xu, Hesong
;
Ding, Xiyao
;
Xu, Ying
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/06/23