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浏览/检索结果: 共914条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 14 作者:  Chen, Yu-jun;  Zhao, Yu;  Yao, Ming-yue;  Wang, Ya-fang;  Ma, Ming   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 acute myeloid leukemia  FLT3  p300/CBP  quizartinib resistance  combination strategy   Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target 期刊论文  OAI收割 NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 12, 页码: 20 作者:  Wang, Hua;  Tang, Shijie;  Wu, Qibiao;  He, Yayi;  Zhu, Weikang   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/02/28 EGFR-mutant lung cancer  adeno-to-squamous transition  tyrosine kinase inhibitor resistance  transcription factor network  RAPGEF3   π-HuB: the proteomic navigator of the human body 期刊论文  OAI收割 NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331 作者:  He, Fuchu;  Aebersold, Ruedi;  Baker, Mark S.;  Bian, Xiuwu;  Bo, Xiaochen   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/04/01 A novel 3D instance segmentation network for synapse reconstruction from serial electron microscopy images 期刊论文  OAI收割 EXPERT SYSTEMS WITH APPLICATIONS, 2024, 卷号: 255, 页码: 17 作者:  Liu, Jing;  Hong, Bei;  Xiao, Chi;  Zhai, Hao;  Shen, Lijun   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/09/09 Synapse  Instance segmentation  Deep learning  Electron microscopy  Connectomics   Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20531-20558 作者:  Hu, Shiliang;  Tong, Linjiang;  Qin, Qiao;  Wen, Jiaxin;  Li, Yan   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/12/11 Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11 期刊论文  OAI收割 CELL METABOLISM, 2024, 卷号: 36, 期号: 10, 页码: 25 作者:  Zhou, Bing;  Luo, Yunchen;  Bi, Hanqi;  Zhang, Ni;  Ma, Mingyue   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/11/26 Insights into Irradiation-affected Structural Evolution and Mechanical Behavior of Amorphous Carbon 期刊论文  OAI收割 Acta Materialia, 2024, 期号: 281, 页码: 120424 作者:  Yeran Shi;  Qiaosheng Xia;  Minda Xie;  Qing Zhou;  Dongpeng Hua   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/01/07 Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21 作者:  Wang, Chaofan;  Fang, Yan;  Zhou, Ziqin;  Liu, Zhuoheng;  Feng, Fang   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/09/26 Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 17 作者:  Zhang, Tao;  Pan, Zilu;  Gao, Jing;  Wu, Qingqing;  Bai, Gang   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/10/21