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The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 115, 页码: 6
作者:
Peng, Cheng
;
Sheng, Li
;
Xu, Gao-Ya
;
Qi, Xiao-Lei
;
Zhou, Yu-Bo
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/12/25
Antileukemic
Thiazolyl
Urea
Synthesis
SAR
Characterization of regolith-hosted rare earth element deposits using reflectance spectroscopy: Framework towards an efficient and reliable field exploration tool
期刊论文
OAI收割
JOURNAL OF GEOCHEMICAL EXPLORATION, 2024, 卷号: 267, 页码: 19
作者:
Li, Martin Yan Hei
;
Liu, Jiacheng
;
Tan, Wei
;
Zhou, Jia-Xi
;
Zhou, Mei-Fu
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/04/01
Rare earth elements
Regolith-hosted deposits
Reflectance spectroscopy
VNIR-SWIR spectroscopy
Clay minerals
Weathering
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Zhai, Lin-hui
;
Jia, Xing-long
;
Chen, Yu-lu
;
Liu, Mu-yin
;
Zhang, Jing-dan
  |  
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2024/12/25
colchicine
MLN4924
multi-omics analysis
phosphoproteomics
ubiquitinomics
kinase inhibitor
Mass balance, metabolism, and pharmacokinetics of [
14
C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Zhao, Chun-Yang
;
Zhang, Li-Jun
;
Sun, Chan
;
Yu, Cheng-Yin
;
Wang, Jian
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/01/06
amdizalisib
PI3K delta kinase
metabolism
mass balance
metabolite identification
pharmacokinetics
safety
Circulating metabolites of
Borneolum syntheticum
(Bingpian) ameliorate atherosclerosis in ApoE
-/-
mice via inhibiting macrophage foam-cell formation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 18
作者:
He, Rong-rong
;
Ma, Chuan-rui
;
He, Xin
;
Dong, Yan-xi
;
Li, Hui
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/11/26
Borneolum syntheticum
Bingpian
borneol
isoborneol
metabolism
atherosclerosis
Three-dimensional reconstruction of Late Miocene
Trapa
from eastern Zhejiang Province, China: Insights into its phytogeography and evolution
期刊论文
OAI收割
JOURNAL OF PALAEOGEOGRAPHY-ENGLISH, 2024, 卷号: 13, 期号: 4, 页码: 954-970
作者:
Xiao, Liang
;
Yuan, Man
;
Ji, De-Shuang
;
Guo, Li-Yan
;
Li, Xiang-Chuan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/03/28
Trapa
Late miocene
Shengxian formation
Three-dimensional reconstruction
Phytogeographic history
Evolutionary history
19
F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Wang, Ze-yu
;
Ren, Yong-mei
;
Hu, Shu-wei
;
Zhang, Nai-xia
;
Dong, Meng-xiao
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/05
COVID-19
simnotrelvir
F-19 qNMR
pharmacokinetics
metabolism
mass balance.
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Gao, Ya-nan
;
Pan, Kai-jun
;
Zhang, Yong-mei
;
Qi, Ying-bei
;
Chen, Wen-gang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/11/05
tofacitinib
depression
JAK-STAT pathway
microgliosis
synaptic defects
Heterozygous variants in USP25 cause genetic generalized epilepsy
期刊论文
OAI收割
BRAIN, 2024, 页码: 16
作者:
Fan, Cui-Xia
;
Liu, Xiao-Rong
;
Mei, Dao-Qi
;
Li, Bing-Mei
;
Li, Wen-Bin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/10/09
genetic generalized epilepsy
USP25
gain of function
loss of function
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1, 页码: 12
作者:
Zhu, Jiajia
;
Chen, Xiao
;
Lu, Bin
;
Li, Xue-Ying
;
Wang, Zi-Han
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/09/10