中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [22]
自动化研究所 [4]
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期刊论文 [39]
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2024 [2]
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Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12735-12759
作者:
Liu, Zhi
;
Jiang, Kailong
;
Liu, Yan
;
Li, Junfei
;
Huang, Siqi
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/09/26
Leros: Learning Explicit Reasoning on Synthesized Data for Commonsense Question Answering
会议论文
OAI收割
Torino, Italia, 2024-5
作者:
Wang, Chenhao
;
Cao, Pengfei
;
Li, Jiachun
;
Chen, Yubo
;
Liu, Kang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/05/30
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/02/19
Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment
期刊论文
OAI收割
JOURNAL OF NANOBIOTECHNOLOGY, 2023, 卷号: 21
作者:
Qingxin, Song
;
Kai, Jiang
;
Dandan, Zheng
;
Linyu, Jin
;
Xiuyuan, Chen
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/11/10
Intervertebral disc degeneration
Gene therapy
DNA hydrogel
Autophagy
Extracellular matrix
Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6
作者:
Xu, Lei
;
Xuyan, Xuyang
;
Minmi, Minmin
;
Wang, Zhiji
;
Shee, Chao
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2023/10/17
Activator
PTPs
Inhibitor
Thieno[2
b ]quinoline derivatives
Diffuse large B-cell lymphoma
The development and benefits of metformin in various diseases
期刊论文
OAI收割
FRONTIERS OF MEDICINE, 2023, 页码: 44
作者:
Dong, Ying
;
Qi, Yingbei
;
Jiang, Haowen
;
Mi, Tian
;
Zhang, Yunkai
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/10/17
metformin
metabolism
cancer
aging
neurological disorder
Examining moisture contribution for precipitation in response to climate change and anthropogenic factors in Hengduan Mountain Region, China
期刊论文
OAI收割
JOURNAL OF HYDROLOGY, 2023, 卷号: 620, 页码: 129562
作者:
Zhang, Xingxing
;
Liu, Zhaofei
;
Liu, Yubo
;
Jiang, Liguang
;
Wang, Rui
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/06/10
tance of YYY
Associate Editor
Hengduan Mountain Region
Moisture source
Climate change
WAM-2layers
Anthropogenic factors
Discovery of toxoflavin,a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 234
作者:
Liu Changmei
;
Nie Litong
;
Jiang Haini
;
Xu Lei
;
Zhang Kunzhi
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/05/22
endoplasmic reticulum stress
toxoflavin
reactive oxygen species
IRE1α
XBP1
Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia
期刊论文
OAI收割
LEUKEMIA, 2022, 页码: 11
作者:
Jiang, Kailong
;
Li, Xuemei
;
Wang, Chang
;
Hu, Xiaobei
;
Wang, Peipei
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/04/10
Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 19
作者:
Yang, Bowen
;
Zhang, Haoran
;
Li, Na
;
Gao, Lixin
;
Jiang, Hong
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2023/04/10