机构

• 上海药物研究所 [20]
• 上海有机化学研究所 [9]
• 大连化学物理研究所 [8]
• 化学研究所 [5]
• 昆明植物研究所 [4]
• 广州生物医药与健康研... [2]
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采集方式

• OAI收割 [55]
• iSwitch采集 [1]

内容类型

• 期刊论文 [55]
• 学位论文 [1]

发表日期

• 2022 [2]
• 2021 [3]
• 2020 [2]
• 2019 [3]
• 2018 [2]
• 2017 [4]
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学科主题

• 生命有机化学 [5]
• Chemistry [3]
• Pharmacolo... [3]
• 金属有机化学 [2]
• Chemistry,... [1]
• Chemistry,... [1]
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筛选

浏览/检索结果: 共56条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 221, 页码: 5 作者:  Chen, Huanhuan;  Zhu, Tingfei;  Sun, Ling;  Xiang, Lili;  Han, Haiyun   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/04/10 Atropisomer  Restricted rotation  Kinetic  Energy barrier  Dynamic HPLC  HSA binding   Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial 期刊论文  OAI收割 CELL METABOLISM, 2022, 卷号: 34, 期号: 5, 页码: 667-+ 作者:  Wang, Jiang;  Zhao, Jing;  Yan, Cong;  Xi, Cong;  Wu, Chenglin   |  收藏  |  浏览/下载：28/0  |  提交时间：2022/08/16 Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group 期刊论文  OAI收割 ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2447-2452 作者:  Xu, Wanbin;  Gong, Xudong;  Odilov, Abdullajon;  Hu, Tianwen;  Jiang, Xiangrui   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/01/18 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid  lifitegrast  methylene  atom utilization   Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20 作者:  Zhang, Rui;  Li, Heng;  Zhang, Xianglei;  Li, Jian;  Su, Haixia   |  收藏  |  浏览/下载：31/0  |  提交时间：2021/05/24 PDE4 inhibitors  Tetrahydroisoquinoline  Antipsoriasis   Asymmetric Total Synthesis of (+)-Quinocarcinamide 期刊论文  OAI收割 ORGANIC LETTERS, 2021, 卷号: 23, 期号: 20, 页码: 7972-7975 作者:  Li,Lei;  Shi,Li;  Wei,Kun;  Yang,Yu-Rong   |  收藏  |  浏览/下载：52/0  |  提交时间：2022/04/02 PRIMARY ALLYLIC AMINES  (-)-QUINOCARCIN  CYCLOADDITION  SUBSTITUTION  CONDENSATION  QUINOCARCIN  ALCOHOLS  ACID   On-DNA Cross-Dehydrogenative Coupling Reaction toward the Synthesis of Focused DNA-Encoded Tetrahydroisoquinoline Libraries 期刊论文  OAI收割 ORGANIC LETTERS, 2020, 卷号: 22, 期号: 15, 页码: 5721-5725 作者:  Wen, Xin;  Duan, Zhiqiang;  Liu, Jiaxiang;  Lu, Weiwei;  Lu, Xiaojie   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/12/24 若干生物碱全合成及铱催化不对称烯丙基-烯丙基交叉偶联反应研究 学位论文  OAI收割 2020 作者:  郑瑜   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/11/02 Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5414-5433 作者:  Guo, Zuhao;  Zhang, Zhuqing;  Yang, Hong;  Cao, Danyan;  Xu, Xiaowei   |  收藏  |  浏览/下载：61/0  |  提交时间：2020/07/01 Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593 作者:  Zhang, Xianglei;  Dong, Guangyu;  Li, Heng;  Chen, Wuyan;  Li, Jian   |  收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01 Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333 作者:  Shao, Jingwei;  Zhu, Kongkai;  Du, Daohai;  Zhang, Yuanyuan;  Tao, Hongrui   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01 PRMT5 inhibitors  N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives  Anti-tumor