中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [23]
金属研究所 [5]
自动化研究所 [4]
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期刊论文 [44]
会议论文 [4]
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2025 [1]
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Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:
Jin, Yuheng
;
Qi, Xuxin
;
Yu, Xiaoli
;
Cheng, Xirui
;
Chen, Boya
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2025/06/23
HDAC7
PROTAC
Selectivity
Hematologic malignancies
Non-enzymatic function
Improved Uniformity of As-Cast Structure, Composition, and Mechanical Properties of 2524 Aluminum Alloy by Intensive Melt Shearing
期刊论文
OAI收割
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE, 2024, 页码: 11
作者:
Zhang, Ying
;
Liu, Xudong
;
Zhu, Qingfeng
;
Zuo, Yubo
;
Chen, Chen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/04/27
aluminum alloy
grain refinement
intensive melt shearing
mechanical properties
macrosegregation
Improved Uniformity of As-Cast Structure, Composition, and Mechanical Properties of 2524 Aluminum Alloy by Intensive Melt Shearing
期刊论文
OAI收割
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE, 2024, 页码: 11
作者:
Zhang, Ying
;
Liu, Xudong
;
Zhu, Qingfeng
;
Zuo, Yubo
;
Chen, Chen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/04/27
aluminum alloy
grain refinement
intensive melt shearing
mechanical properties
macrosegregation
Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12735-12759
作者:
Liu, Zhi
;
Jiang, Kailong
;
Liu, Yan
;
Li, Junfei
;
Huang, Siqi
  |  
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2024/09/26
Leros: Learning Explicit Reasoning on Synthesized Data for Commonsense Question Answering
会议论文
OAI收割
Torino, Italia, 2024-5
作者:
Wang, Chenhao
;
Cao, Pengfei
;
Li, Jiachun
;
Chen, Yubo
;
Liu, Kang
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2024/05/30
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2024/02/19
Understanding of macro-segregation in direct-chill cast 2024 alloy with intensive melt shearing based on the evolution of microstructure and temperature field
期刊论文
OAI收割
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, 2023, 卷号: 27, 页码: 7766-7777
作者:
Zhang, Ying
;
Liu, Xudong
;
Zhu, Qingfeng
;
Zuo, Yubo
;
Wang, Rui
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/04/27
Macro -segregation
Temperature field
Intensive melt shearing
Direct -chill casting
Aluminum alloy
Understanding of macro-segregation in direct-chill cast 2024 alloy with intensive melt shearing based on the evolution of microstructure and temperature field
期刊论文
OAI收割
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, 2023, 卷号: 27, 页码: 7766-7777
作者:
Zhang, Ying
;
Liu, Xudong
;
Zhu, Qingfeng
;
Zuo, Yubo
;
Wang, Rui
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/27
Macro -segregation
Temperature field
Intensive melt shearing
Direct -chill casting
Aluminum alloy
Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment
期刊论文
OAI收割
JOURNAL OF NANOBIOTECHNOLOGY, 2023, 卷号: 21
作者:
Qingxin, Song
;
Kai, Jiang
;
Dandan, Zheng
;
Linyu, Jin
;
Xiuyuan, Chen
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2023/11/10
Intervertebral disc degeneration
Gene therapy
DNA hydrogel
Autophagy
Extracellular matrix
Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6
作者:
Xu, Lei
;
Xuyan, Xuyang
;
Minmi, Minmin
;
Wang, Zhiji
;
Shee, Chao
  |  
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2023/10/17
Activator
PTPs
Inhibitor
Thieno[2
b ]quinoline derivatives
Diffuse large B-cell lymphoma