机构

• 上海药物研究所 [94]
• 计算技术研究所 [7]
• 西北高原生物研究所 [6]
• 大连化学物理研究所 [6]
• 海洋研究所 [6]
• 地理科学与资源研究所 [5]
• 更多

采集方式

• OAI收割 [149]
• iSwitch采集 [2]

内容类型

• 期刊论文 [149]
• 会议论文 [2]

发表日期

• 2025 [2]
• 2024 [14]
• 2023 [9]
• 2022 [12]
• 2021 [19]
• 2020 [6]
• 更多

学科主题

• 生命有机化学 [2]
• Optics [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共151条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY 期刊论文  OAI收割 THERANOSTICS, 2025, 卷号: 15, 期号: 10, 页码: 4325-4344 作者:  Zhang, Zhidan;  Chen, Meijie;  Xu, Yitong;  Wang, Zhihua;  Liu, Zhenghong   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 Atherosclerosis  Hyperlipidemia  ATP-Citrate lyase (ACLY)  lipid metabolism  Isoginkgetin   A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects 期刊论文  OAI收割 DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794 作者:  Liu, Yun;  Yu, Chengyin;  Zhang, Yifan;  Xie, Zhifu;  Wang, Yating   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/04/24 safety  tolerability  pharmacokinetics  pharmacodynamics  BGT-002  novel ACLY inhibitor   Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16 作者:  Nie, Hui-Jun;  Li, Ben-Fu;  Sun, Jingya;  Yuan, Yali;  Zhang, Zhi-Gao   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/11/26 Triple-negative breast cancer  Targeting transcription regulation  Orally bioavailable degrader  PROTAC  Cyclin-dependent Kinase 9   Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 11, 页码: 3476-3489 作者:  Cheng, Tingting;  Song, Gaolei;  Cheng, Long;  Wang, Fan;  Sun, Xinyu   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/02/28 metabolic diseases  ATP-citrate lyase (ACLY)  lipogenesis  ACLY inhibitors  dienyldicarboxylic acid   DPU-Direct: Unleashing Remote Accelerators via Enhanced RDMA for Disaggregated Datacenters 期刊论文  OAI收割 IEEE TRANSACTIONS ON COMPUTERS, 2024, 卷号: 73, 期号: 8, 页码: 2081-2095 作者:  Liao, Yunkun;  Wu, Jingya;  Lu, Wenyan;  Li, Xiaowei;  Yan, Guihai   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/12/06 Central Processing Unit  Engines  Jitter  Computers  Pipelines  Programming  Encryption  Disaggregated datacenter  SmartNIC  RDMA  hardware accelerator   Potential therapeutic strategies for MASH: from preclinical to clinical development 期刊论文  OAI收割 LIFE METABOLISM, 2024, 卷号: 3, 期号: 5, 页码: loae029 作者:  Xie, Zhifu;  Li, Yufeng;  Cheng, Long;  Huang, Yidan;  Rao, Wanglin   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/04 steatosis  inflammation  fibrosis  metabolic dysfunction-associated steatohepatitis  pharmacotherapy   Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 12, 页码: 10035-10056 作者:  Wang, Wen-Jing;  Gao, Lixin;  Wang, Simei;  Huang, Wensi;  Meng, Xin-Yu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/08/20 Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8 作者:  Zhu, Xueran;  Cui, Shumin;  Liu, Xinjing;  Zhang, Mei;  Xie, Zhifu   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/05/31 ATP-Citrate Lyase  BGT-002  Acyl glucuronide metabolite  Pseudo-MRM  LC-MS/MS  Pharmacokinetics   Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity 期刊论文  OAI收割 BIOMOLECULES, 2024, 卷号: 14, 期号: 6, 页码: 21 作者:  Wen, Xueping;  Song, Yufei;  Zhang, Mei;  Kang, Yiping;  Chen, Dandan   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/08/22 18a  adipocytes  polyphenols  thermogenesis  UCP1   Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography 期刊论文  OAI收割 NEUROREHABILITATION AND NEURAL REPAIR, 2024, 页码: 12 作者:  Zhang, Haojie;  Zhao, Jun;  Fan, Lingzhong;  Wu, Xia;  Li, Fang   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/05/30 automated fiber quantification  corticospinal tract  MRI  rehabilitation  stroke  structural plasticity