机构

• 高能物理研究所 [168]
• 近代物理研究所 [54]
• 上海药物研究所 [24]
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• 物理研究所 [1]
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• iSwitch采集 [168]
• OAI收割 [83]

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• 期刊论文 [250]
• 专利 [1]

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• 2025 [2]
• 2024 [10]
• 2023 [6]
• 2022 [3]
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• 2019 [61]
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学科主题

• Physics [1]

筛选

浏览/检索结果: 共251条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21 作者:  Sui, Qibang;  Zhou, Yuanyang;  Li, Manjia;  Wang, Dan;  Cui, Rongrong   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/12/25 Synthetic lethal  MSI tumors  WRN inhibitors  Triazolo-pyrimidine derivatives   SurfDock is a surface-informed diffusion generative model for reliable and accurate protein-ligand complex prediction 期刊论文  OAI收割 NATURE METHODS, 2024, 页码: 24 作者:  Cao, Duanhua;  Chen, Mingan;  Zhang, Runze;  Wang, Zhaokun;  Huang, Manlin   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/01/06 Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity   Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 14 作者:  Tong, Xiaochu;  Qu, Ning;  Kong, Xiangtai;  Ni, Shengkun;  Zhou, Jingyi   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/08/22 Generic protein-ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling 期刊论文  OAI收割 NATURE MACHINE INTELLIGENCE, 2024, 页码: 21 作者:  Cao, Duanhua;  Chen, Geng;  Jiang, Jiaxin;  Yu, Jie;  Zhang, Runze   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/07/12 KinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning 期刊论文  OAI收割 NUCLEIC ACIDS RESEARCH, 2024, 页码: 9 作者:  Li, Zhaojun;  Qu, Ning;  Zhou, Jingyi;  Sun, Jingjing;  Ren, Qun   |  收藏  |  浏览/下载：31/0  |  提交时间：2024/06/27 Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 15, 期号: 5, 页码: 631-639 作者:  Li, Huajie;  Ge, Zhiming;  Lin, Kexin;  He, Wei;  Chu, Qinyu   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/06/27 Hippo pathway  TEAD  PROTAC  Selectivity   Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 14 作者:  Xie, Xiong;  Lan, Qiaoshuai;  Zhao, Jinyi;  Zhang, Sulin;  Liu, Lu   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/05/07 Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity 期刊论文  OAI收割 NATURE IMMUNOLOGY, 2024, 页码: 32 作者:  Long, Xuehui;  Zhang, Sulin;  Wang, Yuliang;  Chen, Jingjing;  Lu, Yanlai   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/03/25