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浏览/检索结果: 共257条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors 期刊论文  OAI收割 SCIENCE TRANSLATIONAL MEDICINE, 2025, 卷号: 17, 期号: 801, 页码: 18 作者:  Yang, Ruirui;  Wang, Bei;  Su, Zhaoming;  Song, Ying;  Zhang, Yingying   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/08/20 Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9 作者:  Li, Linquan;  Gu, Xi;  Meng, Jingyi;  Wen, Yiming;  Yi, Jing   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/05/27 p53 Y220C  Synthesis  Structural modification  Drug design   Discovery and Identification of a Novel PORCN Inhibitor via Structure-Based Virtual Screening 期刊论文  OAI收割 ACS CHEMICAL BIOLOGY, 2025, 卷号: 20, 期号: 6, 页码: 1319-1332 作者:  Yang, Xinyu;  Li, Yanbei;  Zhou, Jingyi;  Zhou, Yuanyang;  Lin, Kexin   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/07/25 Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885 作者:  Hou, Hui;  Zhou, Jingyi;  Sui, Qibang;  Zhang, Changfa;  Su, Zhaoming   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/07/25 Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer 期刊论文  OAI收割 NATURE CANCER, 2025, 页码: 37 作者:  Wang, Hanling;  Zhang, Sulin;  Pan, Qiang;  Guo, Jiacheng;  Li, Ni   |  收藏  |  浏览/下载：14/0  |  提交时间：2025/05/27 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：36/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21 作者:  Sui, Qibang;  Zhou, Yuanyang;  Li, Manjia;  Wang, Dan;  Cui, Rongrong   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/12/25 Synthetic lethal  MSI tumors  WRN inhibitors  Triazolo-pyrimidine derivatives   SurfDock is a surface-informed diffusion generative model for reliable and accurate protein-ligand complex prediction 期刊论文  OAI收割 NATURE METHODS, 2024, 页码: 24 作者:  Cao, Duanhua;  Chen, Mingan;  Zhang, Runze;  Wang, Zhaokun;  Huang, Manlin   |  收藏  |  浏览/下载：23/0  |  提交时间：2025/01/06 Identifying compound-protein interactions with knowledge graph embedding of perturbation transcriptomics 期刊论文  OAI收割 CELL GENOMICS, 2024, 卷号: 4, 期号: 10, 页码: 100655 作者:  Ni, Shengkun;  Kong, Xiangtai;  Zhang, Yingying;  Chen, Zhengyang;  Wang, Zhaokun   |  收藏  |  浏览/下载：19/0  |  提交时间：2025/06/04 Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：38/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity