中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Structural optimization of phthalazine derivatives for anti-HBV activities to improve oral bioavailability
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 10
作者:
Yang, Yurong
;
Xiao, Fuling
;
Zuo, Jianping
;
Yang, Li
;
Hu, Youhong
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
HBV
Capsid assembly modulators
Structural optimization
Oxidative metabolism
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong
期刊论文
OAI收割
PHYTOMEDICINE, 2025, 卷号: 143, 页码: 18
作者:
Jia, Wei-Wei
;
Tian, Nan-Nan
;
Song, Zi-Jing
;
Lan, Xiao-Fang
;
Yang, Xi-He
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Precision medicine
Physiologically based pharmacokinetic model
Ginsenoside
Albumin-facilitated dissociation
Drug interaction
Drug transporter
Hepatic impairment
Study of ultra-high-energy gamma-ray source 1LHAASO J0056+6346u and its possible origins
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 7
作者:
Cao, Zhen
;
Aharonian, F.
;
Axikegu
;
Bai, Y. X.
;
Bao, Y. W.
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2025/06/10
gamma rays
cosmic rays
supernova remnant
young massive cluster
pulsar
Effect of microalloying with La and Nd on adiabatic shear behavior in ultra-coarse grained Cu alloy under quasistatic tensile loading
期刊论文
OAI收割
MATERIALS CHARACTERIZATION, 2025, 卷号: 225, 页码: 13
作者:
Zhang, Mingyi
;
Chen, Kunyu
;
Li, Yang
;
Wang, Wei
;
Zhang, Lehui
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/07/22
Adiabatic shear bands
Cu alloy
Deformation mechanism
Multi-scale
Rare earth
The Overview and Trial Observations of AIMS
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Deng, Yuanyong
;
Wang, Dongguang
;
Hua, Jianwen
;
Xu, Songbo
;
Liang, Ming
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/07/14
Sun: infrared
methods: observational
instrumentation: spectrographs
Diterpenoids and diarylheptanoids from the fruits of
Alpinia
zerumbet
and their anti-inflammatory activity
期刊论文
OAI收割
FITOTERAPIA, 2025, 卷号: 184, 页码: 10
作者:
Zhang, Zhenghan
;
Li, Guangqian
;
Luo, Xin
;
Xiao, Fang
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Alpinia zerumbet
Labdane-type diterpenoid
Diarylheptanoid
Anti-inflammatory
ISG pathway
TDDFT ECD calculation
Climate-induced losses of surface water and total water storage in Northeast Asia
期刊论文
OAI收割
COMMUNICATIONS EARTH & ENVIRONMENT, 2025, 卷号: 6, 期号: 1, 页码: 479
作者:
Zhang, Chenchen
;
Xiao, Xiangming
;
Wang, Xinxin
;
Yi, Shuang
;
Meng, Cheng
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/07/18
Advancing active compound discovery for novel drug targets: insights from AI-driven approaches
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 12
作者:
Wang, Xing-you
;
Chen, Yang
;
Li, Yu-fan
;
Wei, Chao-yang
;
Liu, Meng-ya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
AI-driven drug discovery
novel drug targets
molecular design
ligand exploration
phenotypic drug discovery
undruggable targets
Triconnarins A-D: Four Secophragmalin-Type Limonoids from the Twigs and Leaves of
Trichilia connaroides
期刊论文
OAI收割
ORGANIC LETTERS, 2025, 卷号: 27, 期号: 25, 页码: 6772-6776
作者:
Xu, Jia-Xin
;
Zhao, Hai-Yang
;
Li, Xiao-Zhou
;
Li, Zhi-Ying
;
Shen, Tao
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20