中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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生态环境研究中心 [45]
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期刊论文 [397]
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Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14
作者:
Tian, Lina
;
Xiao, Jian
;
Zeng, Yanping
;
Li, Yangsha
;
Wei, Aihuan
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2025/08/20
CDK9
EZH2
Dual target inhibitor
DLBCL
Preparation and characterization of LGR5 LOOP region-specific nanobodies
期刊论文
OAI收割
PROTEIN EXPRESSION AND PURIFICATION, 2025, 卷号: 229, 页码: 7
作者:
Jia, Li
;
Qiao, Huarui
;
Ding, Yuting
;
Cui, Qianqian
;
Wang, Yingjun
  |  
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2025/04/01
LGR5
Nanobody
Wnt signaling
Topflash
The impact of channel sinuosity and hydrodynamics on fish-habitat suitability in high-gradient meandering rivers
期刊论文
OAI收割
ECOLOGICAL ENGINEERING, 2025, 卷号: 215, 页码: 107586
作者:
Wang, Nan
;
Liu, Shikang
;
Guo, Xiwei
;
Li, Zhiwei
;
Cong, Nan
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2025/04/21
Channel sinuosity
High-gradient rivers
Fish-habitat suitability
Hydro-morphodynamic modeling
Exploring key drivers of Chinese sturgeon spawning sites fragmentation in the Yangtze River: Insights into spawning window
期刊论文
OAI收割
ECOLOGICAL ENGINEERING, 2025, 卷号: 213, 页码: 107563
作者:
Wang, Qianqian
;
Zhong, Yu
;
Yu, Guo-an
;
Li, Zhiwei
;
Ouyang, Lijian
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2025/04/21
Ecohdyraulic modelling framework
Hydro-morpho factors
Habitat quality
Spawning periodicity
Temporal window
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 13
作者:
Wang, Lu
;
Hu, Fangzheng
;
Cui, Qianqian
;
Qiao, Huarui
;
Li, Lingyun
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2025/04/01
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Snow depth and spring temperature dominate the spring phenological shifts and control growing season dynamics on the Tibetan Plateau
期刊论文
OAI收割
AGRICULTURAL AND FOREST METEOROLOGY, 2025, 卷号: 363
作者:
Ma, Qianqian
;
Liu, Ji
;
Li, Xiangyi
;
Li, Yanyan
;
Zeng, Fanjiang
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/11/27
Snow depth
Snow phenology
Vegetation phenology
Climate change
Tibetan Plateau
Emerging Pollutants
期刊论文
OAI收割
PROGRESS IN CHEMISTRY, 2024, 卷号: 36, 期号: 11, 页码: 1607-1784
作者:
Wang, Yawei
;
Zhang, Qiurui
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2025/04/03
emerging pollutants
occurrence level
environmental behavior
ecological risks
control strategies
Zinc ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction
期刊论文
OAI收割
ONCOGENE, 2024, 页码: 11
作者:
Wang, Kangjunjie
;
Chen, Min
;
Yan, Shukun
;
Han, Ying
;
Yuan, Huairui
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/11/26
Nonylphenol displays immunotoxicity by triggering hemocyte extracellular traps in Manila clam via ROS burst, ERK pathway and glycolysis
期刊论文
OAI收割
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2024, 卷号: 285, 页码: 14
作者:
Lv, Xiaojing
;
Han, Yijing
;
Li, Yongxue
;
Wang, Xin
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2024/11/15
Nonylphenol
Extracellular traps
ERK signaling pathway
Reactive oxygen species
Glycolysis