中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
地球化学研究所 [20]
上海药物研究所 [15]
武汉物理与数学研究所 [4]
高能物理研究所 [4]
西安光学精密机械研究... [3]
广州地球化学研究所 [2]
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期刊论文 [63]
会议论文 [3]
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2025 [1]
2024 [7]
2023 [4]
2022 [8]
2021 [8]
2020 [5]
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环境地球化学 [3]
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天文学::太阳与太阳... [1]
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Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 22
作者:
Liang, Xuewu
;
Huang, Yue
;
Ren, Hairu
;
Liu, Qi
;
Chen, Liang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/04/01
Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 17, 页码: 15220-15245
作者:
Saidahmatov, Abdusaid
;
Li, Jianan
;
Xu, Shihao
;
Hu, Xiaobei
;
Gao, Xiangqian
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/10/21
Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12912-12931
作者:
He, Guoxue
;
Zheng, Yueming
;
Chang, Shunzhen
;
Wang, Long
;
Yang, Xiaohao
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/09/26
Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 7, 页码: 5642-5661
作者:
Li, Yuan
;
Xu, Tingting
;
Zhao, Yue
;
Zhang, Hui
;
Liu, Zesheng
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/05/07
Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-
d
]pyrimidin-7(6
H
)-one" Scaffold for the Treatment of B Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906
作者:
Liang, Xuewu
;
Yu, Haolan
;
Liang, Renwen
;
Feng, Zhuanghui
;
Saidahmatov, Abdusaid
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/04/09
Mercury isotope fractionation and mercury source analysis in coal
期刊论文
OAI收割
Science of The Total Environment, 2024, 卷号: 954
作者:
Qingyi Cao
;
Guangyi Sun
;
Liyuan Liu
;
Handong Liang
;
Xuewu Fu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/02/27
Combating air pollution significantly reduced air mercury concentrations in China
期刊论文
OAI收割
National Science Review, 2024
作者:
Xinbin Feng
;
Xuewu Fu
;
Hui Zhang
;
Xun Wang
;
Longyu Jia
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/03/04
Atmospheric Mercury
Long-term Trend
Anthropogenic Emission Reductions
Co-benefits Of Clean Air Action
Using Mercury Stable Isotopes to Quantify Directional Soil-Atmosphere Hg(0) Exchanges in Rice Paddy Ecosystems: Implications for Hg(0) Emissions to the Atmosphere from Land Surfaces
期刊论文
OAI收割
Environmental Science & Technology, 2024, 卷号: 58, 期号: 25, 页码: 11053–11062
作者:
Kun Zhang
;
Qiang Pu
;
Jiang Liu
;
Zhengdong Hao
;
Lijuan Zhang
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/03/19
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
The new direction of drug development: Degradation of undruggable targets through targeting chimera technology
期刊论文
OAI收割
MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54
作者:
Liang, Xuewu
;
Ren, Hairu
;
Han, Fengyang
;
Liang, Renwen
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2024/01/16
chimeric design
degradation System
PROTAC
targeted degradation technology
undruggable targets