中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [133]
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期刊论文 [249]
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Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21
作者:
Sui, Qibang
;
Zhou, Yuanyang
;
Li, Manjia
;
Wang, Dan
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/12/25
Synthetic lethal
MSI tumors
WRN inhibitors
Triazolo-pyrimidine derivatives
Coupling coordination between carbon storage protection in alpine wetlands and SDGs: A case study of the Qinghai-Tibet Plateau, China
期刊论文
OAI收割
JOURNAL OF CLEANER PRODUCTION, 2024, 卷号: 483, 页码: 144260
作者:
Liu, Yuanxin
;
Zhao, Mingyue
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/01/17
Wetland change
Carbon storage
Sustainable development goals
Multi-scenario simulation
PLUS model
InVEST
FAPM: functional annotation of proteins using multimodal models beyond structural modeling
期刊论文
OAI收割
BIOINFORMATICS, 2024, 卷号: 40, 期号: 12, 页码: 12
作者:
Xiang, Wenkai
;
Xiong, Zhaoping
;
Chen, Huan
;
Xiong, Jiacheng
;
Zhang, Wei
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2025/01/14
GENNDTI: Drug-Target Interaction Prediction Using Graph Neural Network Enhanced by Router Nodes
期刊论文
OAI收割
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2024, 卷号: 28, 期号: 12, 页码: 7588-7598
作者:
Yang, Beiyuan
;
Liu, Yule
;
Wu, Junfeng
;
Bai, Fang
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/01/14
DTI
interpretability
graph enhancement
prior knowledge
graph neural network
DTI
interpretability
graph enhancement
prior knowledge
graph neural network
Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14
作者:
Wang, Xudong
;
Xiong, Liwei
;
Zhu, Ying
;
Liu, Sixiu
;
Zhao, Wenfeng
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/12/25
Sodium oligomannate disrupts the adherence of Rib
high
bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice
期刊论文
OAI收割
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 19
作者:
Wang, Xinyi
;
Xie, Zuoquan
;
Yuan, Jie
;
Jin, Enjing
;
Lian, Wen
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/16
Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 15
作者:
Liu, Yadan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/12/16
cGAS-STING signaling
Ginkgetin
senescence
STING inhibitor
target identification
Species diversity and critical habitats of offshore and deep-diving cetaceans in the South China Sea
期刊论文
OAI收割
BIOLOGICAL CONSERVATION, 2024, 卷号: 299, 页码: 14
作者:
Liu, Mingming
;
Lin, Wenzhi
;
Lin, Mingli
;
Dong, Lijun
;
Liu, Binshuai
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/11/18
Cetacean
Important Marine Mammal Area (IMMA)
Relative abundance
Species richness
Dominant species
Xisha-Zhongsha
Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 12
作者:
Suo, Yanrui
;
Qian, Xu
;
Xiong, Zhaoping
;
Liu, Xiaohong
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2024/11/26
Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
期刊论文
OAI收割
ISCIENCE, 2024, 卷号: 27, 期号: 10, 页码: 23
作者:
Du, Runhua
;
Gao, Yanmei
;
Yan, Cong
;
Ren, Xuelian
;
Qi, Shankang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/05