中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Analysis of the shear failure between track slab and CA mortar layer caused by thermal effect for ballastless track
期刊论文
OAI收割
CASE STUDIES IN CONSTRUCTION MATERIALS, 2025, 卷号: 22, 页码: 16
作者:
Zhang, Tao
;
Zhang, Zheyuan
;
Tian, Hongming
;
Lu, Chen
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/06/27
Ballastless track
CA mortar
Constitutive model
Damage analysis
Reanalysis Data Sets Underestimate the 1928-29 Summer Precipitation Deficits During the Late-1920s Megadrought in Northern China
期刊论文
OAI收割
GEOPHYSICAL RESEARCH LETTERS, 2025, 卷号: 52, 期号: 11, 页码: 14
作者:
Fang, Congxi
;
Liu, Yu
;
Sun, Changfeng
;
Song, Huiming
;
Su, Lijun
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/08/18
precipitation reconstruction
drought
tree-ring
reanalysis data
Loess Plateau
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 12, 页码: 12862-12880
作者:
Guo, Jing
;
Tang, Haotian
;
Zhao, Wenchao
;
Li, Yong
;
Song, Shukai
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation
期刊论文
OAI收割
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2025, 卷号: 13, 期号: 5, 页码: 18
作者:
Zhu, Wenting
;
Lu, Shan
;
Jia, Li
;
Liu, Benjin
;
Song, Shanshan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Tumor microenvironment - TME
T cell
Immunotherapy
Immune modulatory
Immune Checkpoint Inhibitor
Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 17
作者:
Zhang, Deyan
;
Liu, Lu
;
Li, Ming
;
Hu, Xinyi
;
Zhang, Xi
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/24
RNA modification
N 6-methyladenosine
Demethylase FTO
Structure-activity relationship
Antileukemia
From waste to soil: The pivotal role of organic matter in soil aggregate formation under dry and wet conditions
期刊论文
OAI收割
PLANT AND SOIL, 2025, 页码: 17
作者:
Lu, Zijing
;
Wang, Hengshuang
;
Liu, Jiazhi
;
Wang, Zhixiang
;
Song, Shaoxian
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/11
Solid waste
Soil organic matter
Soil aggregate
Soil structure
A biomimetic aluminum composite exhibiting gradient-distributed thermal expansion, high thermal conductivity, and highly directional toughness
期刊论文
OAI收割
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2025, 卷号: 213
作者:
Dong, B. Ke
;
Wei, C. Long
;
Lin, J. Chao
;
Xie, L. Lu
;
Liu, K. Ke
  |  
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2024/11/20
Biomimetic materials
Gradient materials
Low thermal expansion
High thermal conductivity
Toughness
New Polyhydroxysteroids Derivatives from Starfish
Asterias amurensis
Induce Embryotoxicity in Marine Medaka
期刊论文
OAI收割
JOURNAL OF CHEMICAL ECOLOGY, 2025, 卷号: 51, 期号: 2, 页码: 14
作者:
Li, Xiaodong
;
Lu, Zhen
;
Wang, Derui
;
Yan, Zhi
;
Yin, Xiuli
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/05/09
Asterias amurensis
Polyhydroxysteroid
Embryotoxicity
Chemical defense
Oryzias melastigma
New Polyhydroxysteroids Derivatives from Starfish
Asterias amurensis
Induce Embryotoxicity in Marine Medaka
期刊论文
OAI收割
JOURNAL OF CHEMICAL ECOLOGY, 2025, 卷号: 51, 期号: 2, 页码: 14
作者:
Li, Xiaodong
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/05/09
Asterias amurensis
Polyhydroxysteroid
Embryotoxicity
Chemical defense
Oryzias melastigma