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浏览/检索结果: 共91条，第1-10条 帮助

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A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H2O2-Triggered Targeted Protein Degradation in Cancer Therapy 期刊论文  OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 147, 期号: 1, 页码: 372-383
作者:  Sun, Jie;  Gu, Mingxi;  Peng, Lvyang;  Guo, Jing;  Chen, Peng
  |  收藏  |  浏览/下载：8/0  |  提交时间：2025/04/01
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20531-20558
作者:  Hu, Shiliang;  Tong, Linjiang;  Qin, Qiao;  Wen, Jiaxin;  Li, Yan
  |  收藏  |  浏览/下载：8/0  |  提交时间：2024/12/11
Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:  Wang, Chaofan;  Fang, Yan;  Zhou, Ziqin;  Liu, Zhuoheng;  Feng, Fang
  |  收藏  |  浏览/下载：10/0  |  提交时间：2024/09/26
Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 17
作者:  Li, Qian;  Zhang, Tao;  Song, Peiran;  Tong, Linjiang;  Feng, Fang
  |  收藏  |  浏览/下载：27/0  |  提交时间：2023/10/17
Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034
作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang
  |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/27
Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割
JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162
作者:  Lai, Mengzhen;  Zhang, Tao;  Chen, Hao;  Song, Peiran;  Tong, Linjiang
  |  收藏  |  浏览/下载：120/0  |  提交时间：2023/04/10
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations br 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:  Chen, Hao;  Lai, Mengzhen;  Zhang, Tao;  Chen, Yuqing;  Tong, Linjiang
  |  收藏  |  浏览/下载：37/0  |  提交时间：2022/08/16
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:  Chen, Hao;  Lai, Mengzhen;  Zhang, Tao;  Chen, Yuqing;  Tong, Linjiang
  |  收藏  |  浏览/下载：17/0  |  提交时间：2024/03/21
Characterizing and analyzing the sustainability and potential of China's cities over the past three decades 期刊论文  OAI收割
ECOLOGICAL INDICATORS, 2022, 卷号: 136, 期号: 0, 页码: 108635
作者:  Wang, Chenxing;  Quan, Yuan;  Li, Xiaoyun;  Yan, Yan;  Zhang, Jing
  |  收藏  |  浏览/下载：18/0  |  提交时间：2022/11/07
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR(T790M/C797S) Mutants 期刊论文  OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 7
作者:  Li, Shan;  Zhang, Tao;  Zhu, Su-Jie;  Lei, Chong;  Lai, Mengzhen
  |  收藏  |  浏览/下载：38/0  |  提交时间：2022/06/15