机构

• 上海药物研究所 [35]
• 西北高原生物研究所 [11]
• 生态环境研究中心 [9]
• 化学研究所 [7]
• 大连化学物理研究所 [4]
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• OAI收割 [93]
• iSwitch采集 [3]

内容类型

• 期刊论文 [89]
• 学位论文 [7]

发表日期

• 2023 [3]
• 2021 [3]
• 2020 [5]
• 2019 [5]
• 2018 [9]
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学科主题

• Biochemist... [2]
• Biophysics [2]
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筛选

浏览/检索结果: 共96条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Zhang, Ying;  Wu, Jianbo   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/01/26 Thieno[3  d ]pyrimidine derivative  Cyclin-dependent kinase 7  Small molecule inhibitor  Kinome selectivity  Triple negative breast cancer   Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者:  Zhang, Junjie;  Li, Yan;  Tang, Haotian;  Zhou, Qianqian;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cancer immunotherapy  HPK1  Structure -based design  HPK1 inhibitor   Chemistry of NH2OH and its related species in the ISM 期刊论文  OAI收割 MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, 2023, 卷号: 523, 期号: 1, 页码: 1-22 作者:  Zhao, Guoming;  He, Mingwei;  Quan, Donghui;  Li, Dalei;  Yang, Xue   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/11/14 astrochemistry  shock waves  ISM: abundances  ISM: molecules   Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034 作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 SyntaLinker  Generative modelling  TBK1 inhibitor  pyrrolo[2  3-d]pyrimidine  Structure-activity relationship   Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 2, 页码: 1243-1264 作者:  Liang, Xuewu;  Tang, Shuai;  Liu, Xuyi;  Liu, Yingluo;  Xu, Qifu   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/06/15 Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen   |  收藏  |  浏览/下载：58/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18 作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng   |  收藏  |  浏览/下载：38/0  |  提交时间：2021/08/17 Axl  Cancer  Inhibitor  Pyrrolo[2,3-d]pyrimidine   紫外辐射诱导的 DNA 嘧啶二聚体损伤检测方法发展与应用研究 学位论文  OAI收割 北京: 中国科学院生态环境研究中心, 2021 作者:  张 宁   |  收藏  |  浏览/下载：6/0  |  提交时间：2022/06/23 紫外辐射  嘧啶二聚体损伤  环丁烷嘧啶二聚体  6-4 光产物  液相色谱-质谱  Dna 测序  免疫沉淀  抗体  文库构建  Uv Irradiation, Pyrimidine Dimeric Lesions, Cyclobutane Pyrimidine Dimers (Cpds), Pyrimidine (6-4) Pyrimidone Photoproducts (6-4pps), Hplc-ms/ms, Dna Sequencing, Immunoprecipitation, Antibody, Library Construction   Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice 期刊论文  OAI收割 TOXICOLOGY LETTERS, 2020, 卷号: 333, 页码: 290-302 作者:  Zhao, Jie;  Xie, Cen;  Wang, Kanglong;  Takahashi, Shogo;  Krausz, Kristopher W.   |  收藏  |  浏览/下载：24/0  |  提交时间：2020/12/21 Triptolide  Transcriptomics  Metabolomics  Apoptosis  Acylcarnitine   2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S (Cys797 to Ser797) mutant 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2020, 卷号: 31, 期号: 5, 页码: 1281-1287 作者:  Hu, Xianglong;  Xun, Qiuju;  Zhang, Tao;  Zhu, Su-Jie;  Li, Qian   |  收藏  |  浏览/下载：80/0  |  提交时间：2020/07/01 EGFR(C797S) mutant  SARs  2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidine  Clinical resistance  Fourth-generation inhibitors