中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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化学研究所 [37]
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合肥物质科学研究院 [28]
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期刊论文 [579]
会议论文 [8]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors
期刊论文
OAI收割
ADVANCED DRUG DELIVERY REVIEWS, 2025, 卷号: 224, 页码: 27
作者:
Zhang, Ping
;
Pan, Jiaxing
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Pancreatic cancer
Cancer immune cycle
Immune resistance
Drug delivery systems
Stimuli-responsive
Preliminary analysis of failure characteristics of the 2025 Junlian rock avalanche, China
期刊论文
OAI收割
LANDSLIDES, 2025, 页码: 13
作者:
Zhao, Bo
;
Zhang, Quan
;
Wang, Lijuan
;
Tian, Hongyan
;
Li, Zhengyou
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/18
Junlian rock avalanche
High shear outlet
Complex zonation
Fragmentation
Wedge topple failure
De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Radio Pulse Search from Aql X-1
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 983, 期号: 1, 页码: 44
作者:
Peng, Long
;
Li, Zhaosheng
;
Pan, Yuanyue
;
Weng, Shanshan
;
Yan, Wenming
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/05/21
Micro-mechanism of basal stresses in steady rock-ice mixture flows: Insights from 2D DEM simulations
期刊论文
OAI收割
COLD REGIONS SCIENCE AND TECHNOLOGY, 2025, 卷号: 231, 页码: 14
作者:
Zhang, Quan
;
Su, Li-jun
;
Dong, Zhi-bo
;
Pan, Yong-liang
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2025/01/24
Rock-ice avalanches
Basal stress fluctuation
Granular temperature
Discrete element method
Soil Moisture Threshold of Methane Uptake in Alpine Grassland Ecosystems
期刊论文
OAI收割
GLOBAL CHANGE BIOLOGY, 2025, 卷号: 31, 期号: 2, 页码: e70062
作者:
Wang, Peiyan
;
Wang, Jinsong
;
Wang, Song
;
D'Imperio, Ludovica
;
Elberling, Bo
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/03/18
alpine grasslands
field transect
methane uptake
regional estimate
soil moisture threshold
Damage evolution characteristics of freeze-thaw rock combined with CT image and deep learning technology
期刊论文
OAI收割
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT, 2025, 卷号: 84, 期号: 1, 页码: 17
作者:
Liu, Hui
;
Dai, Xinyue
;
Yang, Gengshe
;
Shen, Yanjun
;
Pan, Pengzhi
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/06/27
Fissure
Freeze-thaw damage
Deep learning
Intelligent identification
Cellular automaton
Tumor-specific delivery of clickable inhibitor for PD-L1 degradation and mitigating resistance of radioimmunotherapy
期刊论文
OAI收割
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 46, 页码: 17
作者:
Hou, Bo
;
Ye, Jiayi
;
Huang, Lujia
;
Cheng, Wenhao
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/12/16
Air pollution's numerical, spatial, and temporal heterogeneous impacts on childhood hand, foot and mouth disease: a multi-model county-level study from China
期刊论文
OAI收割
BMC PUBLIC HEALTH, 2024, 卷号: 24, 期号: 1, 页码: 12
作者:
Tang, Zhangying
;
Sun, Qi
;
Pan, Jay
;
Xie, Mingyu
;
Wang, Zhoufeng
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/12/30
HFMD
Heterogeneous impacts
Spatiotemporal nonstationarity
Numerical nonlinearity
Small area
China