机构

• 上海药物研究所 [5]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [6]

内容类型

• 期刊论文 [6]

发表日期

• 2026 [1]
• 2025 [3]
• 2022 [1]
• 2021 [1]

学科主题

筛选

浏览/检索结果: 共6条，第1-6条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 307, 页码: 15 作者:  Xiao, Qitao;  Wang, Yuxian;  Shen, Zheyuan;  Mo, Jun;  Li, Cong   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/04/01 MLL-R AML  Menin inhibitor  thieno[2  d ]pyrimidine  Machine learning   Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 12, 页码: 6510-6528 作者:  Guo, Yu;  Song, Yi;  Wang, Hanlin;  Lu, Yang;  Zhang, Jingyu   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/01/29 Degrader-antibody conjugate  Antibody-drug conjugate  Cereblon E3 ligase modulator  Immunomodulatory drug  Molecular glue  Targeted protein degradation  Multiple myeloma  Hematologic malignancy   Discovery of a ubiquitin-specific protease 10 inhibitor with high binding affinity promoting cell apoptosis via down-regulated CDK4 for the treatment of hepatocellular carcinoma 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 17 作者:  Lu, Yang;  Wang, Wentao;  Yuan, Cheng;  Luo, Mengxin;  Wang, Peipei   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 HCC  USP10  Deubiquitination  Binding affinity  CDK4   Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16 作者:  Zeng, Gongruixue;  Xu, Gaoya;  Gao, Lixin;  Zheng, Xiaoli;  Chi, Xinglong   |  收藏  |  浏览/下载：67/0  |  提交时间：2025/04/01 Proteasome inhibitors  Macrocycle  Stability  Anti-cancer activities   Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235 作者:  Qu, Bingxue;  Xu, Yongjin;  Lu, Yang;  Zhuang, Weihao;  Jin, Xinxin   |  收藏  |  浏览/下载：84/0  |  提交时间：2022/12/23 XPO1  Multiple myeloma  MM.1S  N-phenylsulfonamide  Oral administration   Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 5, 页码: 836-845 作者:  Che, Jinxin;  Wang, Zhilong;  Shen, Zheyuan;  Zhuang, Weihao;  Ying, Huazhou   |  收藏  |  浏览/下载：72/0  |  提交时间：2021/08/17 cancer metastasis  CXCR1  CXCR2  selectivity  antagonist  1,5-dihydro-4H-imidazol-4-one